Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"DZNep"”.
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COMBINATORIAL MOLECULAR PHARMACOLOGICAL AND PRECLINICAL STUDIES OF AN EPIGENETIC ANTICANCER DRUG, 3-DEAZANEPLANOCIN A, IN RATS
… cancer cell apoptosis. 3-deazaneplanocin A (DZNep) appears to be a unique chromatin remodelling (epigenetic) compound that can deplete the cellular enhancer of zeste homolog 2 (EZH2) protein, an enzyme responsible for modulation of histone methylation and in turn specifically induce breast …
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The Epigenetics of Small Cell Prostate Cancer
… and H3K9me2) and that EZH2 inhibition with DZNep results in AR re-expression and growth inhibition in AR<sup>-</sup>SCPC cell lines. These data support the hypothesis that AR<sup>-</sup>SCPC are epigenetically distinct from AR<sup>+</sup>ADENO tumors and that epigenetic therapies may reverse …
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Zika Modulates Arthropod Histone Methylation in Mosquito Cells
… to mock-treated controls. Treatment with DZNep, a known EZH2 inhibitor, revealed a decrease in H3K27me3 and ZIKV burden in ZIKV-infected C6/36 cells. In summary, my data suggests ZIKV-associated modulation of SAMe cycle and H3K27me3, critical for its survival in mosquitoes.</p>
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Characterization of Tcl1-Tg:P53-/- Mice That Resemble Human Chronic Lymphocytic Leukemia With 17P-Deletion
… mice to the EZH2 inhibitor 3-deazaneplanocin (DZNep) led to induction of apoptosis, suggesting EZH2 may play a role in promoting CLL cell survival and this may contribute to the aggressive phenotype of CLL with loss of p53. Our study has created a novel CLL mouse model, and suggests that the …
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Comparative Analysis of Heterochromatin in the Anopheles gambiae Complex
… malaria mosquitoes. Different concentrations of DZNep, a histone methyltransferase inhibitor, were administered to An. coluzzii larvae. Total survivorship and pupation were compared for treated and untreated groups. The drug was also administered to adult blood feeding females to determine any …