Global ETD Search
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Showing 1 to 17 of 17 for “"DYRK1A"”.
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A Novel Role For Dyrk1A In Kidney Development
… novel observation that a cohort of patients with DYRK1A haploinsufficiency has a higher prevalence of CAKUT (73% of those assessed), including kidney defects. By using <em>Xenopus laevis</em> as a model we determine that DYRK1A is essential for kidney development. Loss of <em>dyrk1a</em> in …
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Zur Funktion der Kinase Dyrk1A im Gehirn der adulten Maus
… brain size and learning and memory deficits. Dyrk1A is the mammalian homologue of minibrain; the encoded protein is the founding member of the family of Dyrk protein kinases. The human DYRK1A gene is implicated in the emergence of the cognitive deficits in Down syndrome, due to its location on …
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The Discovery and Synthesis of Novel DYRK1A Inhibitors for Various Oncologic Targets
… tyrosine phosphorylation regulated kinase-1A (DYRK1A) as a potential treatment approach for certain DYRK associated pathologies. A series of Groebke–Blackburn–Bienaymé (GBB) based analogs were synthesized and assessed, showing somewhat promising activity. Further profiling of this series has …
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DYRK1A-Related Trabecular Defects in Male Ts65Dn Mice Emerge During a Critical Developmental Window
… Dual-specificity tyrosine-regulated kinase 1a (Dyrk1a) is triplicated in both DS and in Ts65Dn mice and has been implicated as a putative cause of both cognitive and skeletal defects. To test the hypothesis that trisomic Dyrk1a is related to the emergence of trabecular defects at P30, expression …
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Quantifying Dyrk1a During Perinatal Development in the Hippocampus, Cerebral Cortex and Cerebellum of the Ts65Dn
… tyrosine-phosphorylated regulated kinase 1A (DYRK1A) has been linked in DS to neurological deficits by restricting cell growth and proliferation. Little information exists regarding DYRK1A during perinatal development and how its expression may lead to cognitive deficits, and none exists that …
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Generation of genetically modified mice with conditional alleles of Dyrk1a : a minimal animal model of Down syndrome
… identifizierten Genen in dieser Region, ist DYRK1A ein viel versprechendes Kandidatengen für die zahlreichen neurobiologischen Veränderungen. DYRK1A ist über viele Arten hinweg stark konserviert, ubiquitär exprimiert und kodiert für eine Serin/Threonin Kinase. Einige potentielle Substrate von …
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Mechanisms Regulating The P120-Catenin/Kaiso Pathway
… <p>In my second project, I found that the Dyrk1A kinase exhibits a <em>positive</em> effect upon p120-catenin levels. That is, unlike the negative regulator GSK3b kinase, a candidate screen revealed that Dyrk1A kinase enhances p120-catenin protein levels via increased half-life. Dyrk1A is …
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Developmental trajectory of synaptic vesicle recycling in wild type and neurodevelopmental disorder mqodels
… Tyrosine Phosphorylation-Regulated Kinase 1A (Dyrk1A) heterozygous (HET) neurons, which model DYRK1A syndrome, another monogenic NDD that is highly associated with ASD, intellectual disability and epilepsy. DYRK1A is located in the Down syndrome critical region on human chromosome (HSA) 21, …
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Molecular Basis and Modification of a Neural Crest Deficit in a Down Syndrome Mouse Model
… Due to the involvement of the Hsa 21 genes DYRK1A and RCAN1 in regulation of signaling pathways including NFATc (NFAT2), a transcription factor known to influence cellular proliferation and, later, bone development, we hypothesized that dysregulation of these genes could underlie the …
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Characterizing Femoral Structure of the Ts66Yah Mouse Model of Down Syndrome
… tomography. Additionally, the role of trisomic Dyrk1a, a Hsa21 gene previously linked to bone deficits in Ts65Dn mice, was evaluated through genetic and pharmacological means in Ts66Yah femurs at postnatal day 36. Ts66Yah mice were found to have little or no trabecular deficits at any age …
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Genetic determinants of cognitive heterogeneity in Parkinson’s disease
… tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Specifically, I was interested in the genetic contribution to early cognitive decline characteristic of PD (executive function, semantic memory, and episodic verbal learning and memory), as it would enable identification of individuals at …
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Effect of Epigallocatechin-3-gallate on a pattern separation task and hippocampal neurogenesis in a mouse model of Down syndrome
… with DS, including cognitive deficits. DYRK1A is found in three copies in humans with Trisomy 21 and in Ts65Dn mice, and is involved in a number of critical pathways including CNS development and osteoclastogenesis. Epigallocatechin-3-gallate (EGCG), the main polyphenol in green tea, …
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Building a rational model for the identification of allosteric sites
… and showed good selectivity for DYRK2 over DYRK1A by Differential Scanning Fluorimetry (DSF). This oxyamidine hit was further investigated through a structure activity relationship (SAR) which enabled the synthesis of three compounds that showed a higher stabilization than the initial hit …
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Defining novel targets and functions of the protein kinase DYRK2
… based on their sequence homology: class I (DYRK1A, DYRK1B) and class II (DYRK2, DYRK3, DYRK4). Remarkable effort has been spent on identifying the roles of human DYRK1A, a Down syndrome candidate gene that is strongly implicated in neurogenesis, yet the physiological functions and substrates …
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The identification of the Tao-1 kinase as a key regulator of microtubule dynamics
… these screens identified a novel role for Mnb/DYRK1A, a kinase associated with Down’s Syndrome, in the regulation of actin-based protrusions in cell lines derived from neuronal lineages. Furthermore, I identified a single STE20 kinase Drosophila Tao-1 in the core set which was required for the …
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Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules
… phosphorylation-regulated tyrosine kinase, Dyrk1a and, again, the activation of YAP nuclear translocation. Collectively, these results identify both YAP activation and actin cytoskeleton remodelling as major determinants of cardiomyocyte proliferation and establish the molecular basis for …
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Characterising FAM117 proteins as novel targets of DYRK1B
… understudied family of protein kinases. Whilst DYRK1A has garnered more attention due to its links to Downs’ Syndrome and Alzheimer’s Disease, the other class I DYRK, DYRK1B, remains comparatively unexplored. Prior work in our lab has explored potential new DYRK1B substrates by utilising a …