Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"DUSP6"”.
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The Regulation of Oncogenic MAP Kinase Signalling by Dual-Specificity MAP Kinase Phosphatases
… the oncogenic potential of signalling. DUSP5 and DUSP6/MKP-3 are ERK-specific MKPs, which are classical negative feedback regulators of pathway activity, but are differentially localised, with DUSP5 found in the nucleus and DUSP6/MKP-3 in the cytoplasm. However, to date their potential roles in …
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B-RafV600E에 의한 갑상샘 발암과정에서 Thyroid stimulating hormone (TSH) 의 역할연구
… from Patients 4 2. Cloning of B-RafV600E, DUSP6, and c-Myc and Lentivirus Preparation 4 3. Isolation and Culture of Thyrocytes 4 4. Immunohistochemistry and Immunocytochemistry 5 5. Immunoblotiitng 5 6. Analysis of B-RafV600E Mutation 6 7. Immunoprecipitation-Phosphatase Activity Assay 6 8. …
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Elucidating oncogenic mechanisms in human B cell malignancies
… I identified Erk negative feedback control via DUSP6 to be crucial for NRASG12D-mediated pre-B cell transformation and investigated its potential as a therapeutic target. I showed that a small molecule inhibitor of DUSP6 (BCI) selectively induced cell death in patient-derived pre-B ALL cells; …
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Influence de la protéine Pumilio 2 sur le phénotype sénescent induit par les oncogènes
… directement ou indirectement, via la phosphatase DUSP6, par la protéine Pumilio 2. Il est intéressant d’investiguer si la protéine Pumilio 2 pourrait avoir une influence sur le phénotype cellulaire sénescent induit par les oncogènes Ras ou MEK, via la régulation négative de la kinase ERK. …
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Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
… but could not be inactivated by phosphatase DUSP6. I also found that the mutation affected a distal docking site and disrupted interactions with at least some interaction partners at that site. The combined results of this project have shown that this mutation has multiple effects on ERK2 …
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Linking Molecular, Electrical And Anatomical Properties Of Human Epileptic Brain
… of di-phosphoERK, phosphoCREB, EGR1, and DUSP6, suggesting that DUSP4 activation in regions of high interictal activity directly inhibits the spread of electrical activity in these focal regions. These studies utilizing high throughput genomic studies from human neocortex provide great …
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Negative feedback regulation as a means to constrain the oncogenic potential of mutant Egfr in NSCLC
… role for ERK pathway signaling, and specifically DUSP6, in receptor degradation, and solidify the role of the E3 ligase, CULLIN5, in the downregulation of the mutant receptor. The existence of these negative feedback loops may explain the observation that mutation of EGFR is often coincident with …