Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"DUSP4"”.
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Le rôle de DUSP4 dans l'athérosclérose
… s’intéresse particulièrement aux rôles de DUSP4 sur le développement des maladies cardiovasculaires et les maladies rénales. Dans ce contexte, nous avons voulu déterminer le rôle de DUSP4 dans le développement de l’athérosclérose. Quelques études ont révélé qu’une délétion de DUSP1 dans un …
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Linking Molecular, Electrical And Anatomical Properties Of Human Epileptic Brain
… activators and inhibitors of MAPK signaling. DUSP4, a member of a family of dual specificity phosphatases function by inhibiting both isoforms of ERK1/2, is one of the most potent inhibitors of MAPK/CREB signaling. DUSP4 was significantly upregulated in high spiking areas, raising an important …
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Molecular and Genetic Analysis of Neuropeptide Signalling in Mammalian Circadian Timekeeping
… The final chapter focuses primarily on DUSP4, a negative regulator of the MAP kinase pathway that I have demonstrated to be upregulated by VIP. Here I demonstrate that DUSP4 affects the steady-state period of SCN slices, as well as influences phase shifting characteristics of both slices …
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D2R Dopamine Receptor Mediates Changes in Dual Specificity Phosphatase Expression in a Small Cell Lung Cancer Cell Line
… leads to inhibition of the NPA induction of DUSP4 and DUSP5, suggesting phosphatidic acid (PA) produced from Phospholipase D (PLD) is involved in this induction.</p>
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MAP kinase phosphatase-2 in vascular smooth cell muscle function
… aortic smooth muscle cells cultured from a novel Dusp4 knockout mouse exhibit no significant difference in MAP kinase signalling profiles when compared with wild-type. Interestingly however, a significant reduction in proliferation rate corresponded with MKP-2 knockout cells and further cell cycle …