Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"DUB"”.
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Quantitative Deubiquitinase (DUB) Interactomics to Dissect the Biology of Cancer Associated DUBs
… by the class of enzymes called deubiquitinases (DUBs). These DUBs have vital roles in the regulation of protein ubiquitination and have a profound influence on the fate of proteins and their activity. Dysregulation of DUBs has been associated with the development of many human diseases, including …
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The mechanism of chromosome segregation : genetics and cytology of the Drosophila mutants Dub, mei-S332 and ord
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Defining The Functions of Usp22 and Usp44 In Regulation of H2Bub1 Levels
… <p>USP22, part of the deubiquitination module (DUBm) in the SAGA complex, is a well-defined regulator of H2Bub1 levels. ATXN7, another crucial subunit of the SAGA DUBm, is involved in a neurodegenerative disease, spinocerebellar ataxia type 7 (SCA7), due to a polyglutamine (polyQ) expansion in …
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Discovery and characterization of a novel Deubiquitinase ZUP1
Deubiquitinases (DUBs) regulate the post-translational protein modification<br/>ubiquitylation, which is involved in various cellular processes including protein<br/>degradation, an array of signalling pathways and the DNA damage response.<br/>The recent discovery of a fifth family of cysteine …
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Define The Epigenetic Profiles and Subtype-Specific Genes of Breast Cancer
… main deubiquitinase for H2Bub1 is USP22 in the DUB module of the SAGA complex. USP22 is the catalytic subunit of the DUB module. Two adaptor proteins, ATXN7L3 and ENY2, are necessary for DUB activity of USP22 towards histone H2Bub1 and other substrates. ATXN7L3B shares 74% identity with the …
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Mother’s Little Helper: A Memoir in Vignettes
… care. After shooting and killing her husband, Dub, in 1992, she was diagnosed with bipolar and borderline personality disorder by a court ordered psychiatric evaluation and spent four years in state hospitals. Betty battled mood disorders derived from painful childhood memories, and grappled …
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Structural and functional studies of the papain-like protease 2 from mouse hepatitis virus
… system to investigate how the deubiquitinating (DUB) and deISGylating activities of coronavirus (CoV) papain-like protease domains (PLPs) are involved in virus immune evasion. To this end, we chose PLP2 from mouse hepatitis virus (MHV) as our target of study because MHV has historically served as …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
… revealed that WP1130 acts as a partly selective DUB inhibitor. It specifically inhibits the deubiquitinase activity of USP9x, USP5, USP14 and UCH37. WP1130 mediated inhibition of tumor-associated DUBs resulted in down-regulation of anti-apoptotic and up-regulation of pro-apoptotic proteins, such …
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Coronavirus Proteases as Therapeutic Targets: Development of Biosensors to Detect Inhibition of Protease Activity and Separation of the Multiple Functions of Coronavirus Papain-Like Proteases
… in pathogenesis by acting as a deubiquitinating (DUB) enzyme and blocking host immune responses. To determine if PLpro DUB activity is responsible for innate immune antagonism, I mutated residues predicted to interact with ubiquitin and discovered that when this interaction was interrupted, PLpro …
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A new method for measuring and calibrating cinema audio systems for optimal sound quality
… opinions of how well their mix translates from dub-stage to cinema is correlated to how many years they have spent in the industry. The aim of this research is to utilize new methodologies and technology in order to gain insight into how the modern cinema audio system could be calibrated to …
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Evolve : a preliminary multicore architecture for Introspective Computing
… conditions in a system environment. We dub our framework Partner Cores. The Partner Cores framework builds upon tiled multicore architectures [11, 10, 25, 9], closely coupling cores such that one may be used to observe and optimize execution in another. Partner cores incrementally …
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SORTASE AND CHEMICAL BIOLOGY AS TOOLS TO STUDY UBIQUITINATION
… context-specific deubiquitinating enzyme (DUB) probes. We demonstrate early prospects of this strategy to capture DUB enzymes such as USP2 and highlight some key optimization points for future development of this strategy. Finally, we leverage the complementarity of sortase and …
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ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
… BIMEL degradation. Deubiquitylating enzymes (DUBs) remove ubiquitin from target proteins. In the context of BIMEL, DUB activity might oppose E3 ligases and thus cause its accumulation. Until recently the DUB for BIM was unknown however, USP27x has now been suggested. Follow-up validation of …
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REGULATION OF EUKARYOTIC TRANSCRIPTIONAL ELONGATION AND ASSOCIATED DNA REPAIR
… ubiquitination and de-ubiquitination (DUB) by the DUB module of SAGA. It was found that Sus1p, a subunit of the DUB module, promotes transcriptional elongation, DNA repair and replication via regulation of histone H2B DUB. In addition to Rad6p- Bre1p and the DUB module, global level of …
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UCHLI in the Mammalian Nervous System
… Hydrolase L1, is a de-ubiquitinating enzyme (DUB) thought to be involved in ubiquitin recycling. Beyond this, its natural function is almost wholly unknown. Mice lacking this enzyme exhibit a severe and rapidly progressing neurodegenerative phenotype. Using one of these mouse models, in which …
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Meta-metaprogramming
… of their construction, which I collectively dub "meta-metaprogramming." In this thesis, I present three new meta-metaprogramming techniques reducing the work needed to build programming tools, each applicable to the specific problem of sharing implementation code between similar tools for …
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Yellow perch in Lake Michigan: investigating size-selective mortality and alternative estimators of age
Understanding the recruitment dynamic of fishes is a critical component of fisheries research and management. However, the interplay of both biotic (i.e. spawning stock biomass and predation) and abiotic (i.e. water temperature and currents) factors throughout pre-recruit life stages makes …
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Defining Détente: NATO's Struggle for Identity, 1967-1984
… of the 1970s and into the 1980s, leading many to dub the period a “Second Cold War.” What, then, did this mean for the Atlantic Alliance and the double philosophy of détente and defense staked out in the Harmel Report? Defining Détente: NATO’s Struggle for Identity, 1967-1984 explores détente’s …
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Blind but Seeing: Post-clinical Medicine in Jose Saramago's Blindness
… reveals and critiques these changes via a term I dub <em>post-clinical</em>. This demonstrates the ability of literary plague narratives to both understand and critique the medical industry at large.</p>
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Preclinical Study of Potential Antiglioma Novel Tetrahydroisoquinoline Analogs: Pharmacokinetics and Mechanism of Action
… apoptotic effect of EDL-291. Decylubiquinone (dUb) can enhance caspase-3 activation as well as antiproliferative effect caused by EDL-291 treatment. Therefore, dUb could be a candidate companion drug of EDL-291 analogs in treating glioma.</p>
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