Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"DU145"”.
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Effect of broccoli bioactives on prostate cancer cell invasion in vitro
… invasion of human prostate cancer cell line, DU145, in an in vitro model system. DU145 cells were plated into Matrigel invasion chambers placed in 24-well plates with complete growth medium as a chemo-attractant. In the chambers, cells were treated with sulforaphane (SF), indole-3-carbinol …
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The role of PAK6 in HGF-induced prostate cancer cell migration
… the potential role of PAK6 downstream of HGF in DU145 colony-forming prostate cancer cells. These cells exhibit prominent epithelial-cadherin (E-cadherin)-associated cell-cell junctions and ’scatter’ upon HGF stimulation. Studies described here show that HGF addition increases PAK6 …
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Correlation between the expression of integrins and their role in cancer progression. Expression pattern of integrins αvβ3, αvβ5 and α5β1 in clinical and experimental tumour samples
… expressed in variable levels in OSC-19, PC-3, DU145, DLD-1, HT-29, HUVEC, MCF-7, MCF-7ADR and M14 human tumour cell lines and in OSC-19, PC-3, HT-29 and MCF-7 xenografts. α5β1 integrin was expressed in all cell lines and xenografts except in MCF-7 cell line and HT-29 cell line and xenograft. …
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Viral HSV1-TK gene, radiolabeled FIAU, and ganciclovir: combined gene targeted radiotherapy and suicide gene therapy for prostate cancer
… used to transfect the prostate cancer cell line DU145 and the glioma cell line UVW. A viral TK positive, commercially available cell line derived from osteosarcoma (143B-TK) along with its TK-negative clone were also used for comparison. The viral tk gene transfection efficiency was assessed by …
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Roles of Nanog, a transcription factor for self-renewal of embryonic stem cells, in prostate tumor initiation and chemoresistance
… cancer cells. The Nanog-expressing LNCaP-T and DU145 cells were enriched by infection with lentiviruses expressing GFP under the control of Nanog promoter. The Nanog-enriched prostate cancer cells had stronger expressions of stem and progenitor cell surface markers, including CD44 and CD133, …
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Μελέτη του διαφορικού ρόλου των υποδοχέων RPTPβ/ζ και ALK στις βιολογικές δράσεις του αυξητικού παράγοντα HARP και πεπτιδίων του, σε κύτταρα καρκινικών σειρών προστάτη
… την RNAi τεχνολογία, δημιουργήσαμε DU145 και PC3 κύτταρα (κυτταρικές σειρές από καρκίνο ανθρώπινου προστάτη), τα οποία σταθερά έχουν μειωμένα επίπεδα έκφρασης του RPTPβ/ζ και του ALK. Τα DU145 κύτταρα εκφράζουν μόνο τον RPTPβ/ζ, σε αντίθεση με τα PC3 κύτταρα που εκφράζουν και τους …
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The effects of snake venoms as cytotoxins on selected prostate cancer cell lines
… against a panel of prostate cancer cell lines (DU145, PC3, LNCaP) and a non-malignant prostate epithelial cell line (PNT2A). The cytotoxicity activity of each venom was initially assessed using the SYTOX Green assay. SYTOX Green is a fluorescent nucleic acid indicator dye that can be used as a …
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Targeting LEDGF/p75 to Sensitize Chemoresistant Prostate Cancer Cells to Taxanes
… effectively sensitized taxane-resistant PC3 and DU145 cells to DTX and CBZ, as evidenced by a significant decrease in their clonogenic potential. While TRAIL induced apoptotic blebbing, caspase-3 processing, and apoptotic LEDGF/p75 cleavage, which leads to its inactivation, in both taxane- …
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GPR55 and N-acyl Amino Acids
… and control HEK293 cells. In addition, the DU145 a prostate cancer cell line which is reported to endogenously express GPR55 was investigated. N-acyl amino acid challenge activated GPR55 to promote Ca<sup>2+</sup> mobilisation, CREB phosphorylation, actin cytoskeletal reorganisation and …
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Preservation of Bioactive Compounds in Blueberry Fruit
… fractions in LNCaP cells (androgen sensitive) to DU145 cells (androgen insensitive), LNCaP cell growth was dramatically reduced by three pro anthocyanidin-rich fractions (fraction 5 from wild blueberry; fractions 4 & 5 from cultivated blueberry) whereas DU145 cell growth was only slightly …
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Role of cancer stem cells in breast and prostate cancer
… CSC with the CD44+/CD133+ phenotype in PC3, DU145 and LNCAP cells. Using reporter cell lines to further identify the CSC population in SUM159 cell line that express GFP in response to Nanog (NRE-GFP), found that these cells were GFP+ve in the absence of Nanog protein. As these reporters were …
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The Dietary Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells
… detected in prostate cancer cell lines (PC-3 and DU145) in response to biologically-relevant concentrations and short incubations of perillyl alcohol or the mTOR inhibitor—rapamycin.</p> <p>Western blot analysis revealed a decrease in hTERT protein levels in response to either agent that did not …
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The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells
… to inhibit IL-6-induced STAT3 activation in the DU145, LNCaP and PZ-HPV-7 prostate epithelial cells. Elevation of cAMP attenuated IL-6-mediated activation of STAT3 which was mimicked via selective activation of the exchange protein activated by cAMP. Inhibition of protein kinase A (PKA) alone …
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Characterising the mechanism of DCUN1D1 activity in prostate cancer and identifying DCUN1D1 inhibitors for prostate cancer treatment
… proteins that were differentially expressed in DU145 DCUN1D1 knockdown cells relative to DU145 control cells. Interestingly, we did not identify the cullin proteins or classical components of the neddylation pathway but identified the ubiquitin activating enzyme, UBA1. We also found that …
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Characterising the mechanism of DCUN1D1 activity in prostate cancer and identifying DCUN1D1 inhibitors for prostate cancer treatment
… proteins that were differentially expressed in DU145 DCUN1D1 knockdown cells relative to DU145 control cells. Interestingly, we did not identify the cullin proteins or classical components of the neddylation pathway but identified the ubiquitin activating enzyme, UBA1. We also found that …
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Synthesis and evaluation of novel non-viral gene delivery systems for prostate cancer targeting
… uptake of the modified dendriplexes in PC-3, DU145 and LNCaP prostate cancer cell lines. Finally, in vivo studies were carried out using BALB/c nude mice to investigate the anticancer effects of the Lf-bearing dendriplexes encoding TNFα, TRAIL, or IL-12. DAB-Lf significantly increased the …
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Preparation and analysis of novel tumour-targeted delivery systems for prostate cancer therapy
… the in vitro therapeutic efficacy on PC-3, DU145 and LNCaP prostate cancer cells when compared to the non-targeted delivery system, by up to 100-fold in LNCaP cells. In vivo, the intravenous administration of the tumour-targeted therapeutic system encoding Tumour Necrosis Factor (TNF) α …
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A computer model for investigating the biomechanical effects of radiation exposure on pathological and non-pathological living human cells
… point when considering the cell lines PNT2, DU145 and PC3 and greater than 500nm indentation is shown and four different methods are tested and the most robust of these chosen as the method for the distance and cell lines involved. That being ‘line projection’ method created by the author. A …
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Exploring multivalency and chemical modifications in the development of anti-PD-L1 peptide inhibitors for cancer immunotherapy
… peripheral blood mononuclear cells (PBMCs) and DU145 cancer cells. These peptides significantly suppressed cancer cell-mediated T-cell apoptosis, revitalizing T-cells to inhibit the proliferation of cancer cells. Notably, while increasing the valency improved the peptide’s activity, the …
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Profiling the activity of GPR55 antagonists against recombinant and endogenous GPR55
… expresses GPR55 endogenously at high levels (DU145). Antagonist effectiveness was also examined in a neuronal model of Alzheimer’s disease (AD). The effects of the antagonists on LPI-mediated calcium (Ca2+) responses and cAMP-response element-binding protein (CREB) phosphorylation were …
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