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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"DU-145"”.
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LET dependence of radiation-induced bystander effects using human prostate tumor cells
… the ability of irradiated tumor cells to induce bystander effects in co-cultured cells. Human DU-145 prostate carcinoma cells were grown on a 1.4 [mu]m-thick mylar membrane in specially constructed cell culture dishes for irradiation with alpha particles (average energy 3.14 MeV) from a …
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Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer
… primary prostate cells, moderately expressed in DU-145 cells, and highly expressed in invasive PC-3 and PC-3N cells. Using MT1-MMP promoter reporters and mobility shift assays, we show that Sp1 regulates MT1-MMP expression in DU-145, PC-3, and PC-3N cells and in PC3-N cells using chromatin …
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Untersuchungen zur Kombinationswirkung von Valproat und Bestrahlung in Bezug auf klonogenes Überleben, Apoptose, Polyploidie und chromosomale Instabilität in Prostatakarzinom- und Prostatahyperplasie-Zelllinien
… bei den Prostata-Karzinom-Zelllinien (PC-3 und DU-145) und keine Radiosensibilisierung bei den Prostata-Hyperplasie-Zelllinien (BPH-1, PTN-2). Die Ursache dieses Effektes konnte nicht abschließend geklärt werden. Die DU-145-Zellen zeigten eine Erhöhung der Apoptose-Rate durch diese …
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The Production and Characterization of a Monoclonal Antibody to a Naturally Occurring Aminomalonic Acid Epitope and a Comparison with an Antibody to a Synthetically Derived Aminomalonic Acid Epitope
… a source (human prostate cancer cell line, DU-145) of naturally occurring anti-Ama<sub>syn</sub> antibody-reactive protein (DU-145 Ag). A monoclonal antibody, anti-Ama<sub>nat</sub> (IgG<sub>1</sub> kappa), to this antigen was produced which binds specifically to synthetic Ama epitopes and …
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Inhibition des 26s Proteasoms : molekularer Mechanismus der Hyperthermie in Prostatakarzinomzellen?
… in Europa. Die Prognose der Patienten wird durch die Androgenabhängigkeit der Tumorzellen bestimmt. Als Therapiemodalität für das PK wird derzeit in klinischen Studien die Hyperthermie untersucht. Ihre molekularen Mechanismen sind noch nicht bekannt. Wichtige zelluläre Effekte der …
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The anticancer potential of CITme, a quinoline derivative
… revealed cytotoxic activity against HeLa, DU-145, MCF-7, Jurkat and CoLo 320 human derived cancer cell lines at low concentrations. Toxicity was significantly less in either normal resting and stimulated lymphocytes or primary chicken fibroblast cells. CITme showed highest cytotoxic …
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The effect of temperature on the bystander effect as examined in human prostate carcinoma cells with alpha particle irradiation
… irradiated cells release a factor that can produce damage or death in neighboring "bystander" cells that are not actually hit by any radiation. One proposed mechanism involves the irradiated cells releasing a soluble factor into the medium that can cause damage to the non-irradiated cells. …
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Direct and indirect effects of alpha-particle irradiations of human prostate tumor cells
… constructed. Dosimetry of this irradiator was conducted. The average dose rate to the cell monolayer in the specially designed Mylar dish was calculated to be 1.2 Gy/min. In the biological part, three in vitro studies were carried out with the DU-145 human prostate tumor cells using the …
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Role of Nitric Oxide-Signalling in Hypoxia-Induced Immune Escape in Cancer
… increased MICA shedding; however, this hypoxia-induced effect can be attenuated by pharmacological activation of the cyclic guanosine monophosphate (cGMP)-dependent nitric oxide (NO)-signalling pathway in cancer cells. The primary objective of the present study was to determine whether treatment …
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Charakterisierung von Leupaxin und seiner Interaktionspartner in Karzinomzellen
… Erklärungen für diese verstärkte Progression. Durch die Überexpression von LPXN in Prostatakarzinomzellen (PCa) ist sowohl die Migrations- als auch die Invasionsfähigkeit der Zellen erhöht. Untersuchungen des Zelladhäsionsmoleküls p120CTN in den PCa-Zelllinien PC-3 und DU 145 zeigen, dass die …
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JNK regulates Fas receptor mediated apoptosis in prostate cancer cell lines
… apoptosis. Prolonged JNK activity appears to induce the expression of a separate set of genes responsible for promoting apoptosis. Our group has recently shown that activation of JNK by chemotherapeutic drugs can sensitise DU 145 prostate carcinoma cells to Fas receptor mediated apoptosis. In …
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Chemosensory Evaluation of Prostate Cancer Cells
… to discriminate between prostate cancer cells (DU-145 and PC-3) and non-tumor forming cells from the urinary tract (SVHUC). Specific factors that will be investigated are incubation period and cell population. For all three cell lines, two cell populations of 75,000 and 150,000 cells were …
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The effects of jasmonates on the proliferation of human prostate cancer cell lines in culture
… of the prostate cancer cell lines (PC-3 and DU-145), cultured in vitro. In addition, the type of inhibition exhibited by these agents was analyzed using flow cytometry (BrdU assay and Annexin V-FITC/PI staining) and fluorescence microscopy. The mechanism of inhibition was studied using …
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PROGRAMMED DEATH LIGAND 1 (PD-L1) IMMUNE CHECKPOINT-MEDIATED STIMULATION OF MALIGNANT PHENOTYPES IN TUMOUR CELLS
… and characterise the mechanism of PD-1/PD-L1-induced drug resistance; and (c) examine the role of PD-1/PD-L1 signaling on cancer cell invasion and metastasis. Analysis of the TCGA-BRCA dataset indicated a correlation between PD-L1 expression and expression of various genes involved in oncogenic …
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Zur Funktion von Leupaxin beim Karzinom der Prostata
… Läsion in der Prostatadrüse, die erfolgreich durch operative Entfernung des Tumors und lokaler Bestrahlung therapiert werden kann. Patienten mit lokal fortgeschrittener und metastasierender Krankheit werden mit einer Androgen-unterdrückenden Therapie behandelt, die jedoch in 80% der Patienten …
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Tomato Phytochemicals and Prostate Cancer Risk
… carotenoids in tomato cell suspension cultures. DU 145 prostate tumor cells absorbed 14C-15- cis phytoene and an oxidized phytoene product and partially metabolized these compounds in vitro. To elucidate the biological roles of phytoene and phytofluene, it was essential to determine the …
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Design, synthesis, and biological evaluation of dihydronaphthalene and chalcone-based anticancer agents inspired by the natural product combretastatin A-4.
… results in tumor necrosis. The natural product combretastatin A-4 (CA4) is widely accepted as the gold standard of VDAs and the clinical success of its corresponding water-soluble phosphate prodrug salt CA4P has inspired the development of a myriad of analogues and derivatives. Two …
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Cellular response to 11[beta]-dichloro, a novel aniline mustard-estradienone, in various prostate cancer cell lines
… T887A), PC3 (AR-negative, p53 inactive), DU145 (AR-negative, p53 null), and the isogenic pair PC3-AR (AR-positive) and PC3-neo (AR-negative), which only differ in the AR status. Growth inhibition with LNCaP, PC3, and DU 145 cells showed that LNCaP cells are more sensitive to 11 …
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Telomerase Activity in Human Preimplantation Embryos
… blastocyst development. Telomerase positive (DU145 and PMEF) and negative (Hs27 and Detroit 551) cell lines were used to evaluate the assay system followed by the use of discard and donated oocytes and embryos for the comparative evaluation of telomerase activity and maturation level. Immature …
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The identification of prostate cancer associated tumour antigens and biomarkers
… over treatment of potentially indolent disease due to the lack of specificity of PSA for prostate cancer (PCa). PROTEOMEX, a method of tumour associated antigen (TAA) identification, combines the separation of tumour proteins by conventional proteomic methods (2-DE and mass spectrometry) with …
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