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Showing 1 to 2 of 2 for “"DS-epimerase 1"”.
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Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development
… of these GAGs, dermatan/chondroitin sulfate (CS/DS), is attached to proteins either bound to the cell surface or secreted in the extracellular space. CS/DS is a long linear polysaccharide consisting of alternating disaccharide units (i.e. N-acetylgalactosamine and glucuronic acid/iduronic acid). …
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FROM GENE TO STRUCTURE: Formation of Iduronic Acid in Dermatan Sulfate by Two DS-epimerases
… identified that catalyzes this reaction, i.e. DS-epimerase 1 and 2. By using fold-recognition modeling a structural model was obtained for DS-epimerase 1, which enabled characterization of the active site of the enzyme with mutational analysis. A feature of a dermatan sulfate chain is the …