Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"DRUG EFFICACY"”.
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Valuation of the use of biomarkers predictive of drug efficacy to enrich responders in oncology drug clinical development
I study several aspects of the value in performing oncology clinical trials using screening biomarkers to preferentially select and enroll responders. From trial reports and investigational reports on potential biomarkers, I construct a series of six cases comparing the trial as conducted to a …
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Mathematical Models of Hepatitis B Virus Dynamics during Antiviral Therapy
… immune responses, short-term and long-term drug efficacy and the overall health of the liver. A mathematical model was introduced in 2009 to help elucidate the host-virus dynamics after the start of therapy. The model allows the study of complicated viral patterns observed in HBV patients. …
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Drug Design, Biological Activity, and Metabolic Consequences of Cytotoxic Platinum Compounds: Utilizing Fluorescent Tagging to Understand Drug Action and Metabolism
Platinum drugs are among the most commonly used chemotherapeutics for the treatment of testicular, head and neck, ovarian, small cell lung, and colorectal carcinomas. Although the current set of platinum chemotherapeutics has proven somewhat successful, the overall success of platinum based drugs …
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Essays on innovation in health care markets
… presents new evidence on determinants of recent drug overdose mortality. The first chapter examines the effect of financial incentives on reported drug efficacy in clinical trials. I leverage the insight that the exact same sets of drugs are often compared in different randomized control trials …
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Investigate the effect of Bacterial Vaginosis-associated bacteria on the efficacy of Anti-HIV therapy
… prophylaxis (PrEP) with antiretroviral (ARV) drugs such as tenofovir (TFV) and emtricitabine have been shown to protect men who have sex with men (MSM) from HIV infection, PrEP trials have not been as successful for women. Although this disparity is most likely multifactorial, studies have …
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Investigate the effect of Bacterial Vaginosis-associated bacteria on the efficacy of Anti-HIV therapy
… prophylaxis (PrEP) with antiretroviral (ARV) drugs such as tenofovir (TFV) and emtricitabine have been shown to protect men who have sex with men (MSM) from HIV infection, PrEP trials have not been as successful for women. Although this disparity is most likely multifactorial, studies have …
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Genotypes of SNPs of Key Genes Regulate Susceptibility and Drug Sensitivity to Neovascular AMD
… factor (anti-VEGF) therapies, though their efficacy varies across different drugs and individuals, highlighting the importance of precise drug selection in clinical outcomes. Research suggests that factors such as baseline vision, age, disease duration, lesion size, central retina thickness, …
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A TISSUE ENGINEERING APPROACH TO THE DEVELOPMENT OF AN IN VITRO 3D TUMOR MODEL FOR DRUG DELIVERY STUDIES
… good preclinical models has hampered anticancer drug discovery. Standard preclinical protocols require the growth of cells in high throughput two-dimensional culture systems. Such in vitro drug testing methods yield drug efficacy results that differ greatly from animal models. It is conceivable …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… reside and replicate even under antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown to lead to viral rebound independently. In response to the environmental stimuli, macrophages can be polarized into different phenotypes: the …
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Development of implantable devices for schizophrenia treatment
… of neurotransmitters in the brain. One of the drugs that is commonly prescribed to treat schizophrenia is risperidone (RIS). This drug is administered through the oral route (e.g. tablets). Accordingly, the drug is exposed to first-pass metabolism and enzymatic degradation in the …
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Remote controlled drug release in drug-eluting stents
… the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This …
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Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer’s Disease Diagnosis
… enrichment and stratification or to monitor drug efficacy. The aim of the present dissertation is to evaluate diagnostic potential of brain-related proteins in CSF of AD patients. The study was focused on proteins with high specificity for brain tissue. Only proteins expressed predominantly …
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SPINAL MUSCULAR ATROPHY ORGANOIDS REVEAL DEVELOPMENTAL DEFECTS RESCUED BY ANTISENSE OLIGONUCLEOTIDES TREATMENT
… modified SMA natural course, but treatment efficacy remains variable and the reasons beyond this variability are still largely unexplored. Identifying pre-symptomatic SMA features is crucial to define the optimal therapeutic window and most efficient strategy in order to increase drug …
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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters
… sensitive organs from harmful xenobiotics (i.e. drugs, pollutants, etc.) or physiologic changes (i.e. glucose, ion, or water composition). These barriers also express ABC transporters, including P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP), which are known to contribute to …
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The measurement of procedural burn pain and anxiety in paediatric burns : the new BOPAS method
… Hospital, the need to accurately assess pain and drug efficacy and the current lack of specifically designed methods to do so, led to the development of the Burn Observational Pain and Anxiety Scale (BOPAS). This scale is believed to be the first of its kind and was designed to measure both pain and …
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Investigation of in-situ nanoimprinting of cell surface receptors: potential of a novel technique in biomarker research
… history to study disease progression, to develop drugs, or to predict drug efficacy. However, in complex diseases such as in cancer, biomarkers vary tremendously among patients and disease stages. Cell surface receptors, proteins that are located at the cell surface and deliver external signals …
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Utilization of Model-Based Approaches to Maximize Efficacy of Antibiotics for the Treatment of Mycobacterium abscessus Pulmonary Infection
… (CF) patients. Due to the intrinsic multidrug resistance mechanisms and biofilm (BF) formation properties of Mab, effective treatment remains challenging, as these factors significantly diminish the antibacterial activity of drugs. Current treatment guidelines recommend prolonged therapy, …
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Liposomal delivery of PDE5 inhibitors and UT-15C to human erythrocytes
… PAH is to reduce PVR with the administration of drugs such as prostacyclin or its analogs and phosphodiesterase 5 (PDE5) inhibitors. These medications can be used alone or in combination and may have serious unwanted side effects that are additive when used in combination.</p><p>Here an …
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