Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"DRP1"”.
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Drp1 inhibition is protective against mitochondrial and autophagic impairment induced by alpha-synuclein
… the fission protein Dynamin Related protein 1 (Drp1) either genetically or pharmacologically confers protection against these abnormalities. Although further investigation is needed to better understand this protective mechanism, these results are consistent with our previous published data and …
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IMPACT OF DRP1 ACTIVATION, UNFOLDED PROTEIN RESPONSE INDUCTION AND FGF21 LEVELS IN DMD PROGRESSION
… and less interconnected mitochondrial network. Drp1, the master regulator of mitochondrial fission, and its receptors located on the mitochondrial membrane, such as Fis1 and Mff, are responsible for mitochondrial network fragmentation. We found that all these pro-fission proteins are upregulated …
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Investigation of Drp1 inhibition as potential therapy in pesticide-based models of Parkinson's disease
In this study I explored the impact of Drp1 inhibition on pathology in two different pesticide-based models of Parkinson’s disease, and found that paraquat induced autophagy blockade in vitro, which was abrogated by inhibition of Drp1 function through siRNA knockdown or expression of the Drp1K38A …
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The neurotoxic effects of Manganese and the novel protective role of Drp1 in the autophagy pathway
… of inhibiting the mitochondrial fission protein Drp1 were also assessed in these cellular contexts following Mn exposure. Acute exposure to sub-lethal Mn concentrations, in vitro and in vivo, caused an inhibition of autophagy flux in the absence of mitochondrial dysfunction. Despite this, Drp1 …
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Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury
… functional integrity. Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission. Recent studies suggest that i) mitochondrial dynamics, particularly, mitochondrial fission, serves as a mediator of cell fate in the setting of ischemia-reperfusion (IR) injury, and, ii) inhibition …
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Mitochondrial Fission After Traumatic Brain Injury
… fission, Dynamin-related Protein 1 (Drp1), has been implicated as an underlying mechanism associated with excessive fission and neurodegeneration; however, whether dysregulation of Drp1 and excessive fission occur after TBI and contribute to neuropathological outcome is not well …
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Mechanism on Elongated Mitochondria Formation during Iorn Chelation-Induced Senescent Arrest
… Next, we examined expression levels of Drp1 and Mfn proteins, which are known as molecules directly regulating mitochondrial fission and fusion process, respectively. The total cellular expression levels of Drp1 was not significantly changed or decreased, showing diversity of its …
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Preclinical Investigation of Mitochondrial Fission Inhibitors in Pulmonary Arterial Hypertension and Non-Small Cell Lung Cancer
Background: Dynamin-related protein 1 (DRP1)-mediated mitochondrial fission is coordinated with nuclear division. This phenomenon, known as mitotic fission, is increased in hyperproliferative diseases, such as non-small cell lung cancer (NSCLC) and pulmonary arterial hypertension (PAH), due to …
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Characterization of the Helicobacter pylori vacuolating cytotoxin mediated induction of mitochondrial cell death mechanism
… recruitment of the endogenous host protein Drp1, which plays a critical role in the regulation of mitochondrial division within uninfected healthy cells. The dynamic balance between mitochondrial division and fusion is important for maintaining proper functionality of the network. However, …
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Insights into the Functional Link between MtHsp40:MtHsp70 Network and Mitochondrial Homeostasis
… between mtHsp40 and mtHsp70 was dependent on DRP1 level, but mitochondrial translocation of DRP1 was not detected in fragmented mitochondria. In addition, OPA1 short-isoform highly accumulated in fragmented mitochondria, suggesting that ratio between mtHsp40 and mtHsp70 is a determinant of …
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The Effect of Mitochondrial Dynamics on Cell Cycle Progression
… When expression levels of hFis1, Mfn and Drp1 regulating mitochondrial fusion and fission were compared during cell cycle progression, we found that Mfn1 was specifically increased at G2 phase. Finally, we established the HeLa cell lines overexpressing hFis, Mfn or Drp1 genes, which …
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The role of mitochondria in regulating smooth muscle cell proliferation and migration in pulmonary hypertension
… using mitochondrial dynamin-related protein-1 (DRP1) inhibitor Mdivi-1 (10 μM). The signalling proteins and genes were measured by Western blot and real-time qPCR techniques, respectively. Mitochondrial functions were assessed by measuring ATP level, reactive oxygen species (ROS; superoxide and …
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Mitochondrial Dynamics Alteration in Astrocytes Following Primary Blast-Induced Traumatic Brain Injury
… the protein regulator of mitochondrial fission, DRP1, and upregulation in the phosphorylation of DRP1 at the serine 616 site is reported to play a crucial role in astrocytic mitochondrial dysfunction, favoring fission over fusion post-TBI. Astrocytic mitochondria are starting to be recognized to …
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Investigating the function of PINK1 in cancer development and pathogenesis
… defects revealed that dynamin related protein 1 (Drp1)‐mediated mitochondrial fission is enhanced in PINK1‐ deficient MEFs, and that increased expression of Drp1 on mitochondria and activation of Drp1 is highly significant in PINK1‐deficient multinucleated cells. Deregulated and increased levels …
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MITOCHONDRIA FACILITATE VASCULAR INFLAMMATION: THE ROLE OF CANONICAL INFLAMMATORY SIGNALING IN THE REGULATION OF MITOCHONDRIAL MORPHOLOGY
… mitochondrial fission, through DRP1 and MFF, is required for NF-κB activation, VCAM-1 induction and vascular inflammation in vitro and in vivo. In addition, inflammatory signaling in the endothelium mediates mitochondrial fission through an IKKβ/IκBα-dependent pathway. IκBα is …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
… factor (MFF) and Dynamin-related protein 1 (Drp1). Mitochondrial elongation induced by FAM21 depletion was sensitive to fragmentation stimulus, suggesting a secondary role in the process of division. Live cell imaging revealed that FAM21 is dynamically recruited to sites of mitochondrial …
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The Roles of Midzone and Peripheral Mitochondrial Fission in Pulmonary Arterial Hypertension
… by the large GTPase, dynamin-related protein 1 (Drp1), which upon posttranslational activation translocates near the mitochondrial outer membrane (OMM) where it binds partner proteins of the OMM (Mid49, MiD51, MFF and Fis1) creating the fission apparatus that divides the mitochondrion. Recent …
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Reorganization of mitochondrial architecture during apoptosis and mitophagy as investigated by correlative microscopy
… process was compared between cells intact for Drp1, the mitochondrial fission protein, and those with Drp1 knocked out. Fluorescently-tagged Parkin was found on mitochondrial fragments, mitochondria-containing autophagosomes, and mitochondria-containing lysosomes. In both lines, the …
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Structural and Spatiotemporal Organisation of Bax and Apaf1 during Apoptosis
… interactor proteins such as the fission proteins DRP1 and MFF and the mitochondrial matrix chaperone TRAP1. This demonstrates that Bax clusters might sequester various proteins in addition to membrane pieces, possibly favouring the course of apoptosis. Furthermore, correlative light and electron …
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Angiotensin-(1-9) prevents cardiomyocyte hypertrophy via miR-129-3p/PKIA/PKA signaling pathway
… peptide induces mitochondrial fusion through Drp1 phosphorylation and prevented norepinephrine-elicited mitochondrial fission. In the present work, we aimed to elucidate the underlying mechanism by which angiotensin-(1-9) could prevent cardiomyocyte hypertrophy together with its effects over …
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