Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"DREADDs"”.
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Exploring the Behavioural Effects of Compound-21 Using Novel Object Recognition and Object in Place Tests in Long Evans Rats
… Exclusively Activated by Designer Drugs (DREADDs) have gained popularity as a tool to investigate the neural substrates of behaviour in rodents. When used with spontaneous behavioural tests of memory in rodents, DREADDs allow for a unique opportunity to advance our understanding of how …
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Marmoset emotional regulation during adolescence and adulthood, with a particular focus on risk-taking and the role of the subgenual anterior cingulate cortex in motivation and affective biases
… of sgACC in affective biases, specifically, if DREADDs-mediated sgACC overactivation impairs the animals’ ability to show a positive bias toward a stimulus associated with high value food reward. I developed a novel touchscreen-based task to assess affective bias in marmosets, in which during …
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Characterising hippocampal replay in the APP<sup>NL-G-F</sup> mouse model of Alzheimer’s disease
… Exclusively Activated by Designer Drugs (DREADDs) in medial septal cholinergic neurons of ChAT-cre mice. DREADDs were activated using systemic injection of an actuator (CNO), stimulating cholinergic release in the hippocampus and other brain regions. CNO was administered immediately prior …
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The External Globus Pallidus: Bidirectional Control Over Anxiety-Related Behavior Mediated By Crfr1
… Exclusively Activated by Designer Drugs (DREADDs) increases anxiety-related behavior and movement. I show that anxiety-related behavior and movement are decreased in response to activation of Npas1+ neurons, a class of neuron in the GPe that are primarily of the “arkypallidal” subtype. My …
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Investigation of Glutamatergic Circuitry Underlying Copulatory Reward in Female Syrian Hamsters
… exclusively activated by designer drugs (DREADDs) to selectively inhibit these excitatory mPFC efferents. I demonstrated that this selective inhibition decreases sex-induced activation of the NAc, confirming the importance of the mPFC in driving increased glutamatergic activity in the NAc …
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Effects of chemogenetic inhibition of dopamine transporter- or A2A-expressing neurons on spontaneous activity and motivation to consume a palatable food reward
… double transgenic mice that expressed inhibitory DREADDs—designer receptors that are activated only by otherwise inert ligands—only in dopamine transporter (DAT) or A2A adenosine receptor (A2A) expressing neurons, allowing us to transiently inhibit either DA-releasing neurons (DATcre/DREADD) or …
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Investigation of enteric neuron and type 2 lymphocyte interactions at homeostasis and during Nippostrongylus brasiliensis infection
… Exclusively Activated by Designer Drugs (DREADDs) was established using the *Nmu<sup>Cre-iRFP670</sup>* strain. The establishment and study of *Nmu<sup>Cre-iRFP670</sup>* strain has elucidated a significant intestinal neuro-immune circuit for the regulation and potentiation of type 2 …
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Mechanisms of Peripheral Sensitization in Inflammatory Knee Pain
… designer receptors activated by designer drugs (DREADDs) into knee neurons to bi-directionally control excitability in vitro and that Gi- DREADD activation in vivo can reverse a knee inflammation-induced decrease in digging behavior. Findings from this thesis highlight multiple ways to identify …
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An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding
… exclusively activated by designer drugs (DREADDs). However, we were unable to verify the efficacy of clozapine-N-oxide to activate the circuit and opted for an alternative manipulation. We instead inhibited the VTA with direct injections of the GABA agonist, muscimol. This resulted in mice …
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The Role of Neuronal Activity in Adult Myelin Plasticity
In the central nervous system, oligodendrocytes wrap membranes around axons to produce myelin. Their functional roles include rapid neurotransmission, synchronization, and functional maintenance. In the adult brain, 5% or more of the total cellular population consists of oligodendrocyte precursor …
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Neuropeptide FF and Neuropeptide VF and their control in the regulation of energy homeostasis and glucose metabolism
Despite the growing obesity epidemic and its adverse health effects, such as diabetes and cardiovascular diseases, effective treatments are still missing. This is partly due to our insufficient understanding of the regulatory mechanisms underlying energy homeostasis. This work used transgenic and …
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The Role of Glutamate in the Medial Prefrontal Cortex in the Acquistion and Expression of Conditioned Approach
<p>A series of experiments were conducted to assess the role of glutamatergic stimulation in the dorsal and ventral regions of the medial prefrontal cortex (mPFC) in both the acquisition and expression of reward-related learning using a Pavlovian conditioning paradigm, the conditioned-approach …
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Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders
Addictive disorders are a collection of maladaptive behaviors characterized by the uncontrolled use of a rewarding substance. These include substance use disorders, binge eating disorder, certain subtypes of obesity, gambling disorder, and internet gaming disorder. Each of these disorders share …