Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"DREADD"”.
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Exploring the Behavioural Effects of Compound-21 Using Novel Object Recognition and Object in Place Tests in Long Evans Rats
… Exclusively Activated by Designer Drugs (DREADDs) have gained popularity as a tool to investigate the neural substrates of behaviour in rodents. When used with spontaneous behavioural tests of memory in rodents, DREADDs allow for a unique opportunity to advance our understanding of how …
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Effects of chemogenetic inhibition of dopamine transporter- or A2A-expressing neurons on spontaneous activity and motivation to consume a palatable food reward
… double transgenic mice that expressed inhibitory DREADDs—designer receptors that are activated only by otherwise inert ligands—only in dopamine transporter (DAT) or A2A adenosine receptor (A2A) expressing neurons, allowing us to transiently inhibit either DA-releasing neurons (DATcre/DREADD) or …
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Developing tools to investigate neuronal activity in synaptic pruning /
… exclusively activated by designer drugs (DREADD) to inhibit neuronal activity and visualize inhibited neurons. We determined that this DREADD construct is not suitable to perform morphological analysis of axonal boutons and dendritic spines but could be used with other neuron visualization …
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Abnormal cortical activity leads to misallocation of GABAergic interneurons in the mouse neonatal brain.
… Exclusively Activated by Designer Drugs (DREADD) -teknologiaa. Solulaskenta unilateraalisen sensorisen deprivaation jälkeen paljasti GAD67-positiivisten hermosolujen epätavallisen allokaation korteksin syvimpiin kerroksiin viiksistä tulevaa informaatiota käsittelevällä sensorisella …
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Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry
… using the chemogenetic novel hyperpolarizing Gi-DREADD receptor, activated by CNO, we could show that inhibiting the dentate gyrus and CA3 contralateral to optogenetic stimulation effectively halted the afterdischarge progression. The work presented in this thesis reinforces the potential of …
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Neuropeptide FF and Neuropeptide VF and their control in the regulation of energy homeostasis and glucose metabolism
… activation of brainstem NPFF neurons via DREADD technology impaired glucose tolerance, whereas inhibition improved it. In addition, the lack of NPFF signalling leads to a rise in energy expenditure and brown adipose tissue thermogenesis, however, shows impaired high fat diet-induced …
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Mechanisms of Peripheral Sensitization in Inflammatory Knee Pain
… designer receptors activated by designer drugs (DREADDs) into knee neurons to bi-directionally control excitability in vitro and that Gi- DREADD activation in vivo can reverse a knee inflammation-induced decrease in digging behavior. Findings from this thesis highlight multiple ways to identify …
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Actividad del sistema noradrenérgico-locus coeruleus en el dolor neuropático a lo largo del tiempo
… pro-depresiva. Mediante el uso de la tecnología DREADD y el uso de farmacología convencional se moduló la actividad del LC en los diferentes test conductuales. De esta manera, la inhibición global del LCipsi aumentó la sensibilidad al dolor a corto plazo, pero no después. Sin embargo, bloqueo …