Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"DRD2"”.
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The Effect of Stress and Genetic Factors on Alcohol Consumption Among Males in Olancho District, Honduras
… between the neurotransmitter dopamine DRD2 TaqI polymorphism and the onset of alcoholism, with half supporting an association. This study was based on the assumption that there is a relationship between the presence of the DRD2, one’s exposure to stress, and alcohol consumption. We …
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Associations of Single Nucleotide Polymorphisms in the Bovine Prolactin, Melatonin Receptor 1A, and Dopamine Receptor D2 Genes with Hair Coat Shedding Scores and Productivity Traits in Beef Cattle
… quality traits, and the dopamine receptor D2 (DRD2) gene has been associated with hair coat score (HCS) in cattle. Our objective was to determine associations between mutations in the PRL, MTNR1A, and DRD2 genes and cow-calf profitability traits. Genomic DNA was extracted from buffy coat …
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MOLECULAR MECHANISMS UNDERLYING CLINICAL BEHAVIOR OF NEUROENDOCRINE TUMORS: STUDY OF NEW POSSIBLE BIOMARKERS PREDICTABLE OF PHARMACOLOGICAL RESISTANCE AND TARGETS
… receptors (SSTs) and dopamine receptor type 2 (DRD2) in about all NETs that represented, over the years, the main targets for treatment with somatostatin analogs (SSAs) and dopamine agonists (DAs) for these pathologies. Nevertheless, the molecular mechanisms underline pharmacological resistance …
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Flow cytometry quantitation of dopamine receptor D2 loss as a sensitive measure of Huntington's Disease progression in mouse neurons
… under the control of one such dysregulated gene (Drd2), I have improved on previous protocols for the isolation and characterization of adult neurons by flow cytometry. Drd2 is a well-studied marker of a particularly vulnerable population in HD patients, the indirect medium spiny neurons of the …
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Gene discovery: Polymorphism association with obsessive-compulsive disorder and proteome analysis of Artemisia annua.
… flanking the 3’ end of the dopamine D2 receptor (DRD2) gene; Catechol-O-Methyl Transferase (COMT) NlaIII high/low activity polymorphism; 5-HT2A 1438 A/G polymorphism; 5-HT1Dβ G861C polymorphism and the 5-HTTLPR 44-bp deletioninsertion. There was a higher frequency of the DRD2 A2 allele (p = …
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BIOLOGICAL AND ENVIRONMENTAL PREDICTORS OF EXTERNALIZING BEHAVIOR IN LATE CHILDHOOD AND ADOLESCENCE: A TWIN STUDY
… presence of specific dopamine receptor (DRD2 and DRD4) risk alleles, and delinquent peers or siblings would be related to increased externalizing behavior at follow-up. The sample consisted of 65 twin pairs, aged six to 16 (mean age = 9.06 years) who originally participated in the …
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Modeling and Mapping Addiction in the Zebrafish, Danio rerio
… Dopamine Receptors, D1-like (DRD1) and D2-like (DRD2). DRD1 stimulate the neuron by upregulating adenylate cyclase activity, while DRD2 inhibits neurons by blocking or down-regulating adenylate cyclase. Though greatly conserved, the reward system can be hijacked by chemicals that trigger the …
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Dopaminergic Genetic Contributions to Obesity in Kidney Transplant Recipients
… in 7 genes: dopamine receptor type 2 gene (DRD2) single nucleotide polymorphisms (SNPs) rs1800497, rs6277, and rs12364283, dopamine receptor type 3 gene (DRD3) SNP rs6280, dopamine receptor type 4 gene (DRD4) variable number tandem repeat (VNTR), catechol-o-methyltransferase gene (COMT) SNPs …
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The endocannabinoid system in critical neurodevelopmental periods: Focus on its role in the pathophysiology of schizophrenia as neurodevelopmental disorder [Il sistema endocannabinoide nei periodi critici del neurosviluppo: Focus sul suo ruolo nella fisiopatologia della schizofrenia come disturbo dello neurosviluppo]
… per il recettore cannabinoideo CB1) e DRD2 (gene codificante per il recettore dopaminergico D2) mediante pirosequenziamento. Abbiamo anche quantificato il livello di leucociti periferici presenti nel sangue, rispettivamente linfociti, monociti e granulociti mediante la tecnica di …
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METABOLIC ADVERSE EFFECTS INDUCED BY SECOND GENERATION ANTIPSYCHOTIC DRUGS IN PEDIATRIC PATIENTS: PHARMACOGENETIC PROFILING AND MECHANISTIC ANALYSIS OF GENETIC VARIANTS EFFECT IN VITRO MODELS
… rs6275, rs7131056 in D2 dopamine receptor (DRD2) and rs489693 in melanocortin-4-receptor (MCR4). We consider that the identification of these SNPs might provide useful input for personalized and individualized early intervention. Another goal of this project is to examine the direct effect …
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Investigating the Immunological Effect of Schizophrenia-Related Antigens and Anti-psychotic Medication.
… antigens derived from DPYD, MAD1L1, ZNF804A, DRD2, TRANK1 and MMP16 showed an increase in plasma IgG levels and three derived from TSNARE1, TCF4 and VRK2 showed a decrease. As the initial study was conducted with medicated patients with chronic schizophrenia and healthy controls from a …
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Interaction Effects between the Cumulative Genetic Score and Psychosocial Stressor on Drinking Urge and Attentional Bias for Alcohol: A Human Laboratory Study
… index of 5-HTTLPR, MAO-A, DRD4, DAT1, and DRD2 genotypes (candidate genes and environment interaction; cGxE). The current study also examined whether salivary alpha-amylase level or anxiety state mediate the cGxE effects. One hundred five Caucasian young adults (mean age = 19.83; 61% male) …
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Automated, highly scalable RNA-seq analysis
… and found a striking segregation of the Drd1 and Drd2 dopamine receptors into distinct functional zones.
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Anomalies of GABAergic system associated with HIV-1 infection
… with higher interneuronal dopamine receptor 2 (DRD2) expression. Investigation into regional distribution of GABAergic anomaly showed decrease of GABAergic transcripts in all cortical and subcortical brain regions. Low inhibitory tone in the prefrontal cortex was strongly linked to poor verbal …
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Neuronale Korrelate von Delay Discounting
… für den COMT Val 158 Met Polymorphismus, den DRD2 Taq 1 A Polymorphismus und den DAT 1 Polymorphismus ist das Delay Discounting Paradigma an insgesamt 90 Probanden im Magnetresonanztomographen eingesetzt worden, so dass 84 auswertbare Datensätze gewonnen werden konnten. Diese 84 Datensätze …
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Exploring central and enteric nervous system vulnerability in Huntington’s Disease: hints from a knock-in animal model
… proteins under the control of Drd1 and Drd2 promoters, respectively, enabling visualization and differentiation of MSNs. Using this model, we conducted a multidimensional analysis to identify features that contribute to MSNs vulnerability. Transcriptomic analysis of small pools of MSNs …
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Descripción de nuevos correlatos transcripcionales y de nuevas fuentes de biomarcadores en la enfermedad de Huntington
… del cuerpo estriado (por ejemplo, Pde10a, DRD1, DRD2, Ppp1r1b). También se observó la inducción de un programa transcripcional en ratones con menor fenotipo patológico, como posible respuesta homeostática que pudiera ser interesante potenciar en futuras estrategias terapéuticas. Por otra parte, …
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Identification of novel determinants of primary and acquired resistance to EGFR-targeted therapies in colorectal cancer
… cells with acute activators of ER stress eg. the DRD2 antagonist ONC201, in combination with taxanes can be utilised as a novel treatment strategy. Within this chapter we also demonstrated a potential prognostic role for GRP78 expression within a cohort of 156 stage II/III CRC patients. We …
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Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… with VOC (CACNA2D3-rs6777055, P = 0·025; DRD2- rs4274224, P = 0·037; KCNS1-rs734784, P= 0·01). Five pain-related gene variants correlated with hospitalization/consultation rates (COMT-rs6269, P = 0·027; FAAHrs4141964, P = 0·003; OPRM1- rs1799971, P = 0·031; ADRB2-rs1042713; P < 0·001; …