Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"DR5"”.
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Synergic Effect on Cell Death by Co-treatment with TRAIL and Human Anti-DR5 Antibody
DR5 and DR4, death receptors of TNF-related apoptosis-inducing ligand (TRAIL), are interesting targets of antibody-based cancer therapy since TRAIL itself selectively induces apoptotic cell death in cancer cells but not in normal cells. In previous study we isolated a human single-chain variable …
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Sulforaphane sensitizes TRAIL-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated upregulation of DR5
… upregulated mRNA and protein levels of DR5, a death receptor of TRAIL. This was accompanied by an increase in the generation of reactive oxygen species. Pretreatment with N-acetylcysteine and overexpression of catalase inhibited SFN-induced upregulation of DR5 and almost completely …
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Production and Characterization of an Human Monoclonal Antibody IgG to TRAIL Receptor 2
… 은 TNF superfamily에 속하며, 수용성 TRAIL의 경우 DR4와 DR5및 결합하여 다양한 암세포에 세포독성을 가질 뿐 만 아니라, 정상세포에서는 세포독성이 적어 암 치료제로서 가능성이 높게 평가되고 있다. 그러나 수용성 TRAIL의 경우 불안정하며, 사람의 hepatocytes에서 세포독성을 일으킬 수 있고, TRAIL에 의한 저항성을 가지는 암세포 또한 보고된 바 있다. 따라서 현재는 TRAIL을 대체 할 수 있는 TRAIL의 death 수용체를 targeting한 agonistic 항체가 개발되어 …
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Analysis of a novel cytotoxic drug induced TRAIL-R2 signalling complex using a new FACS-based Smac/DIABLO release assay
… inducing complex and modulation by the TRAIL-R2 (DR5). The DR5 modulation appears to be mediated by JNK activation, up regulation of a phosphatase and subsequent dephosphorylation of Bid. Dephosphorylated Bid can be cleaved by active caspase-8 and can then convey the apoptotic signal onto …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… from caspase-8, the death receptor TRAIL-R2 (DR5), which is usually involved in the extrinsic pathway of apoptosis, was found to be required for the execution of 5-FU-triggered cell death. Moreover,following 5-FU treatment, DR5 is not responsible for caspase-8 activation, but for the …
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Development of versatile drug delivery strategies using PLGA nanoparticles
… conjugated with anti Death Receptor 5 (DR5) monoclonal antibodies (mAbs) to target DR5 expressed on the surface of colorectal tumor cells. Anti DR5 mAbs conjugated NP demonstrated specific targeting and internalisation to colorectal carcinoma HCT116 cells, but more interestingly, also …
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N(th)-Order Correlation Functions of Galaxies From the Sloan Digital Sky Survey
… Using photometric redshift catalogs from SDSS DR5 data, I have created two volume limited samples of galaxies, allowing me to measure o N(theta) as a function of type, redshift, and luminosity. I have found that the higher-order bias of early-type galaxies does not vary significantly with …
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Development of novel antibody-targeted nanoparticle strategies for treatment of pancreatic cancer
… ligand (TRAIL) receptor 2/ death receptor-5 (DR5) pathway using the monoclonal antibody conatumumab (AMG 655). However, the results of these clinical trials proved disappointing with no survival advantage being observed. Subsequent literature has suggested that this was most likely due to …
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Μελέτη των αντιγόνων ιστοσυμβατότητας (HLA) σε άτομα με γεωγραφική γλώσσα
… AN INCREASED INCIDENCE OF DRW6, (P<0,01) AND DR5, (P<0,025) ANTIGENS WAS OBSERVED IN THE BLOOD OF THE PERSONS WITH GEOGRAPHIC TONGUE. ON THE CONTRARY, WE OBSERVED A DECREASED INCIDENCE OF THE B51(5), (P<0,05) AND DR2, (P<0,05) ANTIGENS INTHE EXPERIMENTAL GROUP IN COMPARISON WITH THE CONTROLS. …
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Dissection of Regulatory Networks Mediating Resistance and Susceptibility of Arabidopsis thaliana to the Downy Mildew Pathogen Hyaloperonospora parasitica
… pathogen, H. parasitica. Experiments with the DR5
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Characterization of Cytotoxicity against Cancer Cells induced by Human Monoclonal Antibody Specific to TRAIL-R1
… activation of TRAIL-R1 (DR4) and TRAIL- R2 (DR5) with no effect on most normal cells. Also, Tumor cells that are resistant to TRAIL can be sensitized by combination treatment with chemotherapheutic agent or irradiation. But it has also been reported that sTRAIL is able to induce apoptosis of …
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A Dual-GFP Reporter System for Studying Bi-Directional Promotion
… elements. A retinoic acid-responsive element, DR5, was inserted between the SV 40 and TK promoters to test whether this dualreporter vector could be used in characterizing a cA-acting enhancer within this bi-directional promoter region. Reporter expression was minimally induced in retinoic acid …
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Die Rolle der Phosphorylierung von FADD/MORT1
… der Todesrezeptoren CD95, TNF-RI, DR3, DR4 und DR5, spielt eine wichtige Rolle beim Wiedereintritt von ruhenden T Zellen in den Zellzyklus und wird an Serinresten phosphoryliert. Untersuchungen mit dem Phosphorylierungs-spezifischen Antikörper 1C4 wiesen Serin 194 als einzige …
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Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression
… death receptors TNF-R1, Fas, DR4 (TRAIL-R1) and DR5 (TRAIL-R2). c-FLIP binds to the death inducing signalling complex (DISC) via its tandem death effector domains (DEDs) and the DED of Fas-associated death domain-containing protein (FADD), thereby inhibiting processing of procaspases 8 and 10 at …
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The Multifaceted Contribution of Natural Killer Cells During Herpes Simplex Type-1 Viral Infection.
… antigen-bearing immature dermal DCs (CD11c+CD8α-DR5+), that migrate to draining lymphoid organs, to facilitate antigen transfer to lymphoid resident CD8α+ DC for T cell cross priming. 4. 'Helpless' CD8+ T cell function, generated in the absence of CD4+ T cells, can be partially restored to …
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Einfluss von Gibberellin auf den Gravitropismus der Wurzel durch Regulation der PIN-Stabilität
… wurde ein auxinsensitives Promotorkonstrukt (DR5::GFP) verwendet. Interessanterweise akkumulierte nach Gravistimulation bei gleichzeitiger GA-Behandlung Auxin symmetrisch, während bei geringeren GA-Gehalten (Uniconazolbehandlung) keine laterale Auxin Akkumulation erfolgte. Um Veränderungen der …
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Characterisation of auxin and auxin-related genes in the response of Arabidopsis thaliana to salt stress
… stressed plants using two auxin reporter lines, DR5::GUS and DII::VENUS. These analyses showed that IAA levels increased in the shoot and root tip in response to NaCl. Also, local IAA maxima distributed along the primary root of salt stressed seedlings were decreased compared to the untreated …
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Papel del metabolismo de la glutamina en el control de la sensibilidad a trail de células tumorales de mama.
… de la expresión de los receptores TRAIL‐R2/DR5 y una bajada de los niveles de la proteína antiapoptótica FLIP en células TNBC, seguido de una sensibilización a la apoptosis inducida por TRAIL. La quinasa GCN2, cuya activación ocurre en respuesta a la falta de aminoácidos, es responsable de …
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Delineating mechanisms which underlie differential cell fates induced by p53 activation and HDAC inhibition in colorectal cancer
… by inhibiting caspase-8 activation at a TRAIL-R2/DR5 death inducing signalling complex. Notably, the activation of this p53-induced complex occurs independently of canonical TRAIL ligand binding. <br/><br/>In addition to the early induction of caspase-8 dependent apoptotic cell death, this work …