Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"DOCK2"”.
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… The first was a premature stop-gain mutation in Dock2, encoding a GTP exchange factor for the Rac family of cytoplasmic small G proteins, which has previously been found to be critical for T cells and immunity in mice and humans. The second mutation was a synonymous exonic nucleotide substitution …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… The first was a premature stop-gain mutation in Dock2, encoding a GTP exchange factor for the Rac family of cytoplasmic small G proteins, which has previously been found to be critical for T cells and immunity in mice and humans. The second mutation was a synonymous exonic nucleotide substitution …
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New roles of Rac-GEFs in Neutrophils and in Glucose Homeostasis
… to mice deficient in the Rac-GEFs P-Rex1/Vav1, DOCK2 or Tiam1. I demonstrated that Rac activity is increased in RFC Tiam1–/– neutrophils adhering to integrin ligands, which may explain the increased adhesion. In contrast, RFC DOCK2–/– and RFC P-Rex1–/– Vav1–/– neutrophils had reduced Rac …
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Novel Modulators of CD39 and CD73
… were identified using blind docking with CB-Dock2. This protocol was validated by successfully docking ADP and AMP into the active sites of CD39 and CD73, respectively. An ex-vivo assay was conducted to assess the effects of specific CD39 modulators on platelet aggregation, with validation …