Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"DNMT3L"”.
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The Regulation of Dna Methylation In Mammalian Development and Cancer
… DNA methylation. In one project, I show that Dnmt3L, a key regulator of de novo methylation, facilitates Dnmt3a-mediated methylation by stabilizing Dnmt3a2, the major Dnmt3a isoform in mESCs, thus uncovering a new role for Dnmt3L and providing a plausible explanation for the functional …
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Towards elucidating the function of the oocyte Subcortical Maternal Complex: A multi-omic analysis of an Nlrp5-null murine model
… oocytes include epigenetic modifiers DNMT3L and UHRF1, both of which are reduced in the mutant, the former by over 75%, and the latter by 40%. Immunofluorescence analysis of *Nlrp5*-null oocytes indicates an altered DNMT3L localisation, but no change in DNMT1 localisation. Single-cell …
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Regulation of De Novo and Maintenance Dna Methylation By Dnmt3A and Dnmt3B
… factors also play critical regulatory roles: DNMT3L (DNMT3-like) facilitates <em>de novo</em> methylation by DNMT3A/3B, and UHRF1, a 5mC reader, targets DNMT1 to hemi-methylated CpG sites during DNA replication to facilitate maintenance methylation.</p> <p>The finding that 5mC can be converted …
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Contribution of Lsh to DNA methylation reprogramming in embryonic stem cell, epiblast stem cell and embryoid body model systems
… with their catalytically inactive co-factor Dnmt3l, while these DNA methylation patterns are maintained through cell divisions by maintenance methyltransferase Dnmt1. The exact mechanisms by which these DNA methyltransferase enzymes are targeted to specific genomic regions remain unclear, but …
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Investigating the molecular dynamics of gene re-silencing following treatment with epigenetic therapies
… in the expression of the DNMT3A, DNMT3B or DNMT3L genes. Finally, despite the persistence of the repressive histone mark H3K9me3 following 5-Aza-dC treatment we find that, in this model, inhibitors of H3K9 methyltransferases do not delay gene re-silencing. These findings show that gene …