Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"DNMT"”.
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Alterations in the Hippocampal Epigenome as a Result of Alcohol Exposure During the Perinatal Period of Development in Rats
… deacetylase (HDAC) and DNA methyltransferase (DNMT) was measured in hippocampal tissue of 21 day old rats. Alcohol exposure during development led to an increase in DNMT, but not HDAC, activity in both sexes. The data are consistent with the possibility that epigenetic modifications may be a …
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Étude du lien antagoniste existant entre la méthylation de l'ADN et le variant d'histoire H2A.Z : rôle du complexe TIP60/P400
… le cas des inhibiteurs de méthyltransférases (Dnmt). Il a été démontré que les fonctions aberrantes des Dnmt sont fréquemment associées à la tumorigenèse. Effectivement, les Dnmt semblent responsables de l’hyperméthylation des gènes suppresseurs de tumeurs ainsi que de l’instabilité génomique, …
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Epigenetic Modification as a Therapeutic Target in BRAFV600E-mutated Metastatic Colorectal Cancer
… phenotype. Firstly, DNA methyltransferase (DNMT) inhibitor treatment induced profound DNA hypomethylation in vivo, but minimal change in gene expression due to adaptive elevation of the repressive histone methylation, H3K27me3, leading to compensatory suppression of key tumor suppressor …
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Accumulation of perfluorooctanoic acid in intestine and lung tissues and its effect on gene expression across multiple pathways
… analysis targeting epigenetic regulators (Dnmt and Tet) in these tissues, with additional focus on tight junction genes in intestinal tissue and genes involved in pathogen infection pathways in lung. PFOA has accumulated across all tissues which increased proportionally in a dose dependent …
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DNA Methylation and DNA Methyltransferases in the Clonal Raider Ant, Ooceraea biroi
… methylation and DNA methyltransferase enzymes (DNMTs) are ubiquitous and predate the origin of eukaryotes. In animals, DNA methylation primarily is carried out by DNMT1, which targets hemi – methylated DNA and maintains methylation patterns through cycles of cell replication, and DNMT3, the de …
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Synthetic approaches to the understanding of DNA nucleobase methylation
… is catalyzed by the DNA methyltransferases (DNMTs). Among different mammalian DNMTs, DNMT1 is the most abundant and active, and plays multiple roles in carcinogenesis, embryonic development, and several other biological functions. Reactivation of silenced tumor suppressor genes by DNMT …
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Epigenetic modelling: DNA methylation and working towards model parameterisation
… mechanism controlled by DNA methyltransferase (DNMT) enzymes. This thesis provides a brief introduction to epigenetics, a survey of ongoing research on computational epigenetics and a description of the DNA methylation database. Furthermore, it also gives an overview of DNA methylation and its …
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Application of High-Performance Liquid-Chromatography Mass-Spectrometry Platform to Study Metabolism and Epigenetic Control of Metabolism
… proliferate uninhibited. There are two de novo DNMTs, DNMT3A, and DNMT3B. These DNMTs establish the pattern of methylation. We examined de novo DNMT-mediated control of cellular metabolism, identifying global changes in metabolism, as well as differential sensitivity towards glycolytic and …
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The role of the PWWP domain in the DNA methyltransferase 3A targeting to the genome
… established by DNA methyltransferase (DNMT) enzymes, regulates gene expression and is essential for mammalian development. Histone tail post-translational modifications modulate the recruitment and activity of DNMTs. In particular, the PWWP domains of DNMT3A and DNMT3B are posited to …
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Methyl-CpG-Binding domain proteins and histone deacetylases in the stage-specific differentiation of olfactory receptor neurons
… silencing, catalyzed by DNA methyltransferases (DNMTs) and mediated by methyl binding domain proteins (MBDs) and histone deacetylases (HDACs), is essential for mammalian development, with the nervous system demonstrating particular sensitivity to perturbations. Little is known, however, about the …
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Roles of the ING1 Epigenetic Regulator in Breast Cancer
… but the combination of ING1b with 5azaC (DNMT inhibitor), thus targeting two distinct epigenetic mechanisms, was more effective. Adenoviral delivery of ING1b combined with 5azaC also inhibited cancer cell growth in a xenograft model and led to tumor regression. These data showed that …
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The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
… of histone deacetylases, DNA methyltransferases (DNMTs), and aurora kinase A (AurkA) can promote neuroblast differentiation and decrease proliferation. The combination of the DNMT inhibitor decitabine with the AurkA inhibitor MLN8237 enhances differentiation and reduces proliferation compared to …
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Predicting protein-DNA interactions using statistical modeling and biophysical representations of high-throughput sequencing data
Proteins are the cell’s most abundant component, excluding water, and participate in almost every biological process. Their functions include gene regulation, metabolic catalysis, molecular transportation, immune defense, and other critical roles. Such diverse capabilities arise from their …