Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"DNAm"”.
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Exploring Veto Activity: DNAM-1-CD155 Axis in Overcoming NK Cell-Mediated Allo-Rejection and Applications for CAR-T Cell Therapy
… a primary ligand for the activating receptor DNAM-1. Later in vitro studies further indicated that conjugation between veto Tcm cells and alloreactive NK cells induces NK cell anergy by enhancing the internalization and degradation of DNAM-1, a process significantly linked to the activation of …
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Maternal Adverse Childhood Experiences and Infant DNA Methylation: Examining an Epigenetic Biomarker of Intergenerational Risk
… stress” may also predict DNA methylation (DNAm; one component of epigenetics) in offspring, potentially impacting developmental health outcomes. Thus, the purpose of this study was to investigate the association between human mothers’ preconception stress and differential DNAm patterns in …
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Multiomic Investigation of the Human Gut Toward Insight into Childhood Inflammatory Bowel Disease Pathogenesis
… However, my study revealed DNA methylation (DNAm) is generally lost and becomes more variable the longer organoids are cultured. My findings suggest a major impact of prolonged culturing on global organoid DNAm profiles, highlighting the importance of considering time in culture in organoid …
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Characterization of DNA methylation and gene expression profiles in post-traumatic stress disorder
… with PTSD, specifically DNA methylation (DNAm) and gene expression profiles, exhibit tissue specificity and are comprised of two dynamic components: 1) profiles reflecting cellular composition and 2) alterations in DNAm levels at CpG sites and transcriptional activity. In this work, I …
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Understanding and stratifying brain health through blood-based omics data
… measure available from blood is DNA methylation (DNAm), which is an epigenetic mechanism that can regulate gene expression and protein levels. DNAm is thought to record the body’s response to a range of biological and environmental factors. The first aim of this thesis is to perform methylome-wide …
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Interaktionen von dendritischen Zellen und Effektorzellen der frühen antitumoralen Immunabwehr
… (NKp46, NKp44, NKp30) und Korezeptoren (2B4, DNAM-1) auf NK-Zellen demonstriert, welche essentiell für die NK-Zell-vermittelte Erkennung und Lyse von Tumorzellen sind. In weiteren Untersuchungen induzierten LPS-aktivierte slanDCs eine erhebliche Produktion von Interferon (IFN)-gamma in …
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Mitochondrial mechanisms in autism spectrum disorder: characterizing the neurotoxic effects of propionic acid in vitro
… cohort reported differential DNA methylation (DNAm) signatures converging on mitochondrial metabolism and Propionyl CoA Carboxylase B (PCCB). This project aimed to better characterise the mitochondrial component of ASD aetiology using an in vitro system to mechanistically interrogate the …