Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"DNA-protein interaction"”.
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The functional significance of the G to A point mutation in the promoter region of the Apolipoprotein AI gene
… the point mutation was assessed by analysing the DNA-protein binding and promoter activities of the different alleles. This data would suggest that the point mutation alters the function of the apoAI promoter as gel retention assays revealed that the G fragment (-140 to +10) formed an extra …
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Human Gonadotropin-Releasing Hormone (hGnRH) Gene Expression and Hormone Regulation in Human Placental JEG-3 Cells
… demonstrated the involvement of Oct-1 in the FP4 DNA-protein interaction in JEG-3 cells.</p> <p>Transient transfection studies showed that hERα and hERβ mediate inhibitory effects of estradiol on the hGnRH upstream promoter in JEG-3 cells in a receptor-mediated and dose-dependent manner, while …
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Functional significance of unique sequences in Mycobaterium smegmatis Ku proteins
… to the non-homologous end-joining pathway of DNA double strand break repair, first discovered in eukaryotes and more recently in prokaryotes and archaea. This study concerns the importance of two unique sequence features of Ku protein from Mycobacterium smegmatis that include a lysine-rich …
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On the Repair of DNA Breaks and the Specificity of the EcoRI Restriction Enzyme
<p>We would like to understand how proteins and enzymes interact with DNA. We describe here our studies of the Mrr methylation dependent restriction system, DNA single- and double-strand break repair in E. coli, and substrate recognition by the EcoRI endonuclease. Many species of bacteria make …
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Transcriptional regulation of the human alpha 2(I) procollagen gene
… collagen gene by analysing trans-acting factor interactions within the proximal promoter of the gene and to identify the genes coding for these trans-acting factors. α2(1) procollagen gene expression was examined in a number of diff erentiate<;l cell lines and shown to differ significantly …
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DNA supercoiling with a twist
The level of torsion in double-stranded DNA regulates base-pair stability and DNA conformation. It is important in initiation and regulation of specific DNA metabolic processes as well as chromatin assembly. High mobility group proteins (HMGB) are architectural proteins whose HMG DNA binding …
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Developing high-resolution methods to study DNA and RNA dynamics
Nucleic acids, including DNA and RNA, are one of the most important biomacromolecules inside the cell. DNA stores genetic information, while RNA has more versatile roles including conveying and deciphering genetic information, catalyzing biological reactions, conducting post- transcriptional …
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DNA double-strand break repair studied by atomic force microscopy
DNA double-strand breaks (DSBs), where both strands of the DNA duplex are simultaneously fractured, are considered the most lethal type of DNA damage. The conserved Mre11-Rad50 DNA repair complex enables the catalytic activities of the Mre11 nuclease and the Rad50 ATPase to function together to …