Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"DNA-protein binding"”.
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Nucleic Acid Structural Recognition by Transcription Factor AmrZ and Riboendonuclease HI
DNA regulation is a fundamental part of every cell's life cycle. The expression of DNA allows cells to respond, adapt, and live in the ever changing environment and even overcome host cell defenses. This regulation is controlled through DNA-protein binding. Proteins bind to an innumerable amount of …
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The functional significance of the G to A point mutation in the promoter region of the Apolipoprotein AI gene
… the point mutation was assessed by analysing the DNA-protein binding and promoter activities of the different alleles. This data would suggest that the point mutation alters the function of the apoAI promoter as gel retention assays revealed that the G fragment (-140 to +10) formed an extra …
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Human Gonadotropin-Releasing Hormone (hGnRH) Gene Expression and Hormone Regulation in Human Placental JEG-3 Cells
… demonstrated the involvement of Oct-1 in the FP4 DNA-protein interaction in JEG-3 cells.</p> <p>Transient transfection studies showed that hERα and hERβ mediate inhibitory effects of estradiol on the hGnRH upstream promoter in JEG-3 cells in a receptor-mediated and dose-dependent manner, while …
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Transcriptional and Post-transcriptional Control of Nhlh2 with Differing Energy Status
… and females. Nhlh2 regulates other genes by binding to the E-box in the promoter region of these genes. This transcription factor regulates many other transcription factors including MC4R and PC1/3 which are associated with human obesity. The Nhlh2 promoter has been analyzed for putative …
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Transcriptional Regulation of Melanocortin 4 Receptor by Nescient Helix-Loop-Helix-2 and its Implications in Peripheral Energy Homeostasis
… It regulates the transcription of genes by binding to the E-Box binding sites present in the promoter region. Here in this dissertation, Nhlh2's role as a transcriptional regulator of Mc4r and the effects of deletion of Nhlh2 on peripheral energy expenditure, glucose homeostasis and fatty …
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Statistical methods for ChIP-seq and microbiome studies using next-generation DNA sequencing data
… data with biological replicates to identify protein-binding sites. Chapters 3-4 are about analysis of microbiome data to estimate the causal effects of microbiome features on interesting outcomes in presence of confounding variables.</p> <p>ChIP-seq experiments aim to detect DNA-protein …
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A Statistical Model to Determine Multiple Binding Sites of a Transcription Factor on DNA Using ChIP-seq Data
<p>Protein-DNA interaction is vital to many biological processes in cells such as cell division, embryo development and regulating gene expression. Chromatin Immunoprecipitation followed by massively parallel sequencing (ChIP-seq) is a new technology that can reveal protein binding sites in genome …
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Zero-Inflated Models to Identify Transcription Factor Binding Sites in ChIP-seq Experiments
<p>It is essential to determine the protein-DNA binding sites to understand many biological processes. A transcription factor is a particular type of protein that binds to DNA and controls gene regulation in living organisms. Chromatin immunoprecipitation followed by highthroughput sequencing …