Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"DNA-drug"”.
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Development of a TSM Biosensor for the Determination of DNA- Drug Interactions: A Novel Method to Assist Drug Development
… and kinetics of binding of chemotherapeutic drugs to DNA are generally time consuming and/or expensive. Moreoxer. a combination of approaches is required if both the mechanism and the kinetics of binding are to he determined, e.g. LJV spectroscopy can be used to determine the kinetics of …
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Biochemical studies of targeted and bimodal analogues of the natural anticancer compounds combretastatin A-4 and illudin M
… mechanism of apoptosis induction. The proposed drug uptake was analysed using specific inhibitors to disable certain transporters/carriers. Changes in the shapes of cellular and sub-cellular components resulting from drug treatment were observed by light microscopy, immune-fluorescence …
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Novel Development of Super-Resolution Force Spectroscopy and Applications in Biological Systems
… has unique biophysical applications in studying drug-DNA interactions and ribosomal translocations. I demonstrate that SURFS has a high force resolution of 0.5 pN by resolving the dissociation forces of 12 base pairs of DNA duplex and 11 base pairs of DNA duplex with the drug daunomycin. The …