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Showing 1 to 6 of 6 for “"DNA topoisomerases"”.
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Dynamics of human DNA Topoisomerases I and II
… tool for investigating the cell biology of human DNA topoisomerases. Our most important finding was, that both types of mammalian topoisomerases are entirely mobile proteins that are in continuous and rapid flux between all compartments of the nucleus and between the cytososl and the chromosomes …
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Studies on Type I and Type II DNA Topoisomerases From Mammalian Mitochondria
<p>Mammalian mitochondria contain a unique DNA topoisomerase I with characteristics of both nuclear and bacterial type I DNA topoisomerases. This enzyme, purified from bovine liver, requires cations as cofactors and possesses optimal activity at pH 7.0, 37°C and either 150 mM K+ or Na+ ions. …
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DNA FRAGILE SITE BREAKAGE AS A MEASURE OF CHEMICAL EXPOSURE AND PREDICTOR OF THE SUSCEPTIBILITY TO FORM CHROMOSOMAL REARRANGEMENTS
… chromosomal translocations which require DNA breakage. These DNA breaks can occur through exogeneous chemical exposures and/or at regions particularly susceptible to breakage termed “common fragile sites (CFS)”. To test the hypothesis that fragile site breakage underlies the formation of …
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Anticancer Potential of Soy Peptides
… activities of L1210 leukemia cells and human DNA topoisomerases. Bioactive peptides were isolated and identified by a co-immunoprecipitation approach coupled with nanoLC-Q-TOF-MS/MS. Soy protein hydrolysates produced by simulated gastrointestinal digestion induced L1210 cytotoxicity through …
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Harnessing CRISPR-Cas9 screens to identify functional genetic interactions
… we demonstrated that RAD54L2 can counter TOP2-DNA genotoxic adducts, ultimately preventing DNA double-strand break formation and adding a layer of intricacy to the cellular mechanisms that safeguard the genome from TOP2-mediated DNA damage. Since etoposide is widely used for cancer …
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ΦΩΣΦΟΔΙΕΣΤΕΡΟΛΥΤΙΚΗ ΔΡΑΣΗ ΣΕ ΚΥΤΤΑΡΟΠΛΑΣΜΑ ΣΥΚΩΤΙΟΥ ΠΟΝΤΙΚΟΥ C3HB. ΚΑΘΑΡΙΣΜΟΣ ΚΑΙ ΜΕΛΕΤΗ ΙΔΙΟΤΗΤΩΝ ΤΕΣΣΑΡΩΝ ΕΝΖΥΜΩΝ
THE ACID RIBONUCLEOLYTIC ACTIVITY OF MOUSE LIVER CYTOPLASM IS DUE TO 2 RIBONUCLEASES. THEY ARE LOW MOLECULAR WEIGHT ENZYMES THAT RESIST ACID CONDITIONS BUT ARE DESTROYED AT 100 K FOR 10 MIN . THE ENZYMES SHOW DIFFERENT PRETENCES TOWARDS END-LABELLED NATURAL SUBSTRATES (55 RNA). RNASE I SHOWS THE …