Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"DNA sensors"”.
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Sensor applications of carbon nanotubes
… Using this overview of carbon nanotube-based sensors, specific sensor technologies that could benefit from the use of newly developed techniques for producing aligned and ordered bundles of carbon nanotubes were selected. Reports of chemical/gas, biological, optical, mechanical, and a few …
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… of viral nucleic acids. Many intracellular DNA sensors induce the expression of pro-inflammatory cytokines and type I interferons (IFN) through the activation of the transcription factors including IFN regulatory factor 3 (IRF3). Interestingly, we found evidence that the same defense …
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Development of Functional DNA -Based Sensors and Investigations Into Their Mechanism
… vitro selection. In vitro selection to isolate DNAzymes for Hg2+ and Cd2+ and the use of negative selections to overcome Pb 2+ interference at various stages of selection has been described in Chapter 5. Chapter 6 describes the structure-switching strategy to isolate DNA aptamers specific for …
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TREX1 DNASE ACTIVITY IS REGULATED BY PHOSPHORYLATION AND MACROPHAGES LACKING TREX1 HAVE IMPAIRED EFFEREOCYTOSIS
… found in metazoan cells. TREX1 acts on both ssDNA and dsDNA and functions to prevent adverse immune activation by degrading cytosolic nucleic acids that would otherwise activate DNA sensors resulting in interferon production. Mutations in TREX1 cause multifactoral, systemic autoimmune diseases. …
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The role of NLRP3 and AIM2 inflammasomes in dental pulp inflammation and reparative processes
… novel roles for NLRP3 inflammasomes and DNA sensors in this process.<br/><br/><i>Thesis is embargoed until 31 July 2026.</i>
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An examination of the role of IFI16 in detecting viral DNA in human immortalised keratinocytes
The presence of exogenous DNA in the cytosol results in the activation of the DNA sensor cyclic GMP-AMP synthase (cGAS). cGAS produces the second messenger cyclic GMP-AMP (cGAMP) which binds to and activates the endoplasmic reticulum adapter STimulator of INterferon Genes (STING). Activated STING …
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2D materials based nanopore structures as single molecule sensors
Nanopores are impedance based bio-sensors. The principle of nanopore sensors is analogous to that of a Coulter counter. A nanoscale aperture (the nanopore) is formed in an insulating membrane separating two chambers filled with conductive electrolyte. Charged molecules are driven through the pore …
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Atomically thin microwave biosensors
… developed for graphene direct-current (DC) sensors. The new RF sensors shown in this work inherit the strong response of graphene at low analyte concentrations, while enabling RF methods at concentrations not possible before. This is shown by limit of the detection for glucose, based on RF …
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TREX1 C-Terminus Regulates Oligosaccharyltransfererase to Prevent the Accumulation of an Endogenous Bioactive Disaccharide Associated with Autoimmune Disorders
… Detection of viral and bacterial intracellular DNA by cytosolic DNA sensors (CDS) is crucial for the activation of the innate immune system and for eliciting a proper immune response. However, self-DNA species that originate from retro-elements, genomic DNA replication, and damaged mitochondria …
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Charge-Modulated Field-Effect Transistor: technologies and applications for biochemical sensing
… interest in the last decades, as electronic sensors can represent as valuable, portable and low cost alternative to the bulk, expensive laboratory instrumentation. Among the biochemical reactions, genetic processes have been thoroughly investigated in literature: in particular, DNA …
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Development of functional DNA-based sensors and investigations into their mechanism
… paradigm in nucleic acid chemistry. Catalytic DNA molecules also known as deoxyribozymes or DNAzymes were first isolated in 1994 through an in vitro selection procedure and have since been engineered and isolated to perform various functions that include both RNA and DNA cleavage and ligation. …
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Development of a TSM Biosensor for the Determination of DNA- Drug Interactions: A Novel Method to Assist Drug Development
… kinetics of binding of chemotherapeutic drugs to DNA are generally time consuming and/or expensive. Moreoxer. a combination of approaches is required if both the mechanism and the kinetics of binding are to he determined, e.g. LJV spectroscopy can be used to determine the kinetics of binding and …
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Regulation of type I interferons in murine dendritic cells
… preventing accumulation of excessive cytoplasmic DNA, avoiding cell-intrinsic innate DNA sensor activation and suppressing activation of both type I IFN-stimulated and IFN-independent antiviral genes. Trex1 also helps HIV escape cytoplasmic detection by DNA sensors. However, regulation of Trex1 in …
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Chemo and biodetection in liquid with organic transistor
… realization of portable devices, i.e. chemical sensors capable to analyse small quantities in situ. Nowadays, the availability of portable devices allows to test those samples which are di�cult or impossible to transport for long distances without degradation. This work concerns the realization …
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Alternative signal transduction for functional nucleic acid sensors
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01