Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"DNA repeats"”.
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NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION
Genomic DNA is organized around the double-stranded of B-form DNA, which is both durable and flexible enough to store and pass on genetic information. Once freed from the associations of an extended complimentary sequence, single stranded DNA and RNA can adopt a vast array of stable secondary …
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NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION
Genomic DNA is organized around the double-stranded of B-form DNA, which is both durable and flexible enough to store and pass on genetic information. Once freed from the associations of an extended complimentary sequence, single stranded DNA and RNA can adopt a vast array of stable secondary …
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Antigenic Variation and Telomere Structure in Trypanosoma brucei
… effect. Telomeres typically contain simple DNA repeats (TTAGGG in animals and trypanosomatids) that are the binding sites for telomeric proteins, and end in 3' protrusions known as overhangs. In mammals, telomeres fold back in structures known as t-loops, in which the overhang is …
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Centromere Identity and the Nature of the Cenp-A-Containing Nucleosome
… While most centromeres form on repetitive DNA, the underlying DNA sequence is neither necessary nor sufficient to support centromere function, suggesting that this locus is epigenetically defined. The histone H3 variant centromere protein A (CENP-A) replaces H3 in nucleosomes at the …
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RNA-binding Proteins and RNA-DNA Hybrids Regulate Repetitive DNA Stability in Health and Disease
… to proper cellular function. Repetitive DNA sequences, such as the ribosomal DNA repeats (rDNA) and transposons, represent a large portion of eukaryotic genomes. Due to their repetitive nature, these loci are prone to aberrant recombination. In fact, rDNA repeat instability and increased …
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Telomere Structure and Shortening in Telomerase-Deficient Trypanosoma brucei: Implications for Anitgenic Variation
… are nucleoprotein complexes consisting of tandem DNA repeats and proteins that bind to them. Their function is to protect chromosome ends from the DNA repair machinery that would otherwise recognize them as double-stranded breaks. With the help of the ribonucleoprotein telomerase they compensate …
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THE DNA DAMAGE CHECKPOINT REGULATES MISMATCH REPAIR COMPLEXES DURING SINGLE STRAND ANNEALING PATHWAY
… The vast majority of lesions are single-strand DNA breaks caused by physiological processes such as DNA replication or oxidative stress during cellular metabolism. Moreover, single-strand DNA breaks can be converted to DNA double-strand breaks (DSBs), which are the most dangerous form of DNA …
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Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
… act as parasites to bacteria by ejecting their DNA into the cell and hijacking host machinery to produce more viral particles. Once new phage particles are assembled inside the cell, the bacterium will lyse, leading to not only to the death of the bacterium but also the proliferation of more …
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The Role of Adaptor Proteins in rDNA Double-Strand Break Repair by Homologous Recombination
… by a number of endogenous as well as exogenous DNA damaging agents. Among the various lesions, DNA double strand breaks (DSBs) represent a particularly deleterious threat for a cell. In order to maintain genome stability and integrity, cells have evolved a highly organized network of cellular …
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Understanding Meiotic Recombination and Genomic Organisation of Plant Species
… megabase-long arrays of centromeric tandem repeats. While new long-read DNA sequencing technologies allow for more accurate assembly across the centromeres, methods for their annotation are also required. In this thesis, I present the development of Tandem Repeat Annotation and Structural …
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Rekonstrukce repetitivních elementů DNA
… práce obsahuje hlavní klasifikaci repetitivní DNA a představuje implementaci nového de novo assembleru, zaměřeného na hledání a sestavení LTR retrotranspozonů a satelitní DNA. Assembler přijímá na svém vstupu krátké ready (single nebo pair-end), získané sekvenátory druhé generace (NGS). Tento …