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Showing 1 to 20 of 585 for “"DNA repair"”.

  1. DNA repair in bacteroides fragilis

    Steffens, Laura SioneDepartment of Molecular and Cell Biology2008

    … chemically reactive compounds interact with DNA causing strand breaks and base mutations; the damage accumulates and leads to cell death. Mechanisms of metronidazole resistance in B. fragilis include decreased activity of oxidation/reduction enzymes, over-expression of multidrug efflux pumps …

    cape-town Repository record

  2. DNA repair and sister chromatid exchange

    Hagelstrom, R. Tanner, author, Bailey, Susan M., advisor, Liber, Howard, advisorColorado State University. Libraries2008

    … of SCE within telomeric regions. The role of DNA repair in SCE regulation and formation is also under investigation. While it has been shown that at least one of the DNA repair pathways, homologous recombination (HR), is likely to be involved in the formation of SCE, it is less clear whether …

    colostate Repository record

  3. DNA repair mechanisms: implication in cancer

    Habraken, YvetteULiège - Université de Liège1999

    liege Repository record

  4. DNA repair in Bacteroides fragilis Bf-2

    Abratt, Valerie RoseDepartment of Molecular and Cell Biology1987

    Repair deficient mutants of Bacteroides fragilis have been isolated in order to study the responses of this organism to various DNA damaging agents at the physiological and molecular levels. Two types of mutants were isolated by ethyl methane sulphonate mutagenesis of B.fragilis followed by …

    cape-town Repository record

  5. Repair eXtreme - DNA repair proteins from Antarctic extremophiles

    Rzoska-Smith, ElizabethThe University of Waikato2023

    … from Antarctic DV systems may possess unique DNA repair enzymes and pathways that enable their survival in such extreme conditions. Exploring these DNA repair systems may offer valuable insights into microbial survival in extreme environments or even extra-terrestrial settings. To investigate …

    waikato-masters Repository record

  6. A DNA repair-independent pathomechanism in Cockayne syndrome

    Alupei, Marius-CostelUniversität Ulm

    ulm-diss Repository record

  7. Folate Deficiency and Its Effect On Dna Repair

    Noxon, Virginia

    … cancer. Folate is required for faithful DNA synthesis because a folate derivative is utilized to synthesize an important DNA precursor, thymidylate. Deprivation of thymidylate causes the incorporation of uracil into DNA, which is removed by Base Excision Repair (BER). The role of BER in …

    south-carolina Repository record

  8. REGULATORY MECHANISMS OF TRANSCRIPTION AND ASSOCIATED DNA REPAIR

    Malik, Shivani

    … the degradation of RNA polymerase II stalled at DNA lesion facilitating the rapid repair of transcriptionally active genes through a process of transcription coupled repair (TCR). My studies have addressed the key question of the fate of RNA polymerase II stalled at a lesion. My findings show …

    siu-theses Repository record

  9. Somatic mutagenesis in humans with deficient DNA repair

    Robinson, Philip SUniversity of Cambridge2022

    … with germline heterozygous mutations in the DNA polymerase genes POLE and POLD1. Chapter 4 summarises the investigation of somatic mutagenesis in normal tissues from individuals with germline MUTYH mutations. In Chapter 5 findings from the two cancer predisposition syndromes are compared and …

    cambridge Repository record

  10. Molecular mechanisms of DNA repair in Mycobacterium tuberculosis

    Gessner, Sophia JohannaDivision of Medical Microbiology2017

    The mycobacterial DNA damage and repair pathways involved in the emergence of drug-resistance during host infection remain poorly understood, yet are critical to any efforts to develop novel "anti-evolution" drugs aimed at reducing the capacity of Mycobacterium tuberculosis to adapt genetically …

    cape-town Repository record

  11. DNA repair and genomic instability in yeast aging

    Park, Peter Unnam, 1971-Massachusetts Institute of Technology2002

    … be evolutionarily conserved. Extrachromosomal rDNA circles (ERCs) have been identified to be a cause of replicative aging in budding yeast S. cerevisiae. Genomic instability can cause ERCs to excise from chromosomal rDNA arrays, containing 35S and 5S rRNA genes. At each cell division, ERCs …

    mit Repository record

  12. DNA repair proteins Metnase and PARP1 regulate DNA integration

    Nie, Jingyi, author, Nickoloff, Jac A., advisor, Bailey, Susan M., committee member, Liber, Howard L., committee member, Chen, Chaoping, committee memberColorado State University. Libraries2015

    DNA integration occurs naturally in various formats and plays important roles in evolution. DNA integration also affects human and animal health. Various genome-editing tools have been developed based on site-specific DNA integration. In mammalian cells, DNA integration is largely random. The …

    colostate Repository record

  13. Investigation of Huntingtin’s Role in DNA Repair and Transcription

    Snowden, Jeffrey DavidThe University of Texas Medical Branch at Galveston2022

    … as a member of the nuclear Transcription-Coupled DNA Repair (TCR) complex. Both wild type and mHTT were shown to interact with several nuclear DNA repair and transcription proteins, including PNKP, RNA Polymerase, DNA ligase III, CREB, and Ataxin3 (Atxn3). HTT is directly implicated in regulating …

    utmb Repository record

  14. Npsd4: A New Player In Sumo-Dependent Dna Repair

    Atkinson, Erin, <p>0000-0003-3898-5688</p>2023

    … of damage and stress. Improper resolution of DNA damage lesions can lead to mutations, oncogene activation, and genomic instability. Difficult-to-replicate-loci present barriers to DNA replication that, when not properly resolved, lead to replication fork stalling and collapse and genomic …

    uthsc Repository record

  15. REGULATION OF EUKARYOTIC TRANSCRIPTIONAL ELONGATION AND ASSOCIATED DNA REPAIR

    Sen, Rwik

    … DUB module, promotes transcriptional elongation, DNA repair and replication via regulation of histone H2B DUB. In addition to Rad6p- Bre1p and the DUB module, global level of histone H2B monoubiquitination is also critically regulated by Cdk9, a kinase essential for phosphorylation of the serine 2 …

    siu-theses Repository record

  16. Role of DNA repair protein ERCC1 in skin cancer

    Song, LiangThe University of Edinburgh2009

    Nucleotide excision repair (NER) is one of the major repair systems for removal of DNA lesions. The NER pathway has evolved mainly to repair UV-induced DNA damage and is also active against a broad range of endogenously generated oxidative lesions. Defects in NER result in the human inherited …

    edinburgh Repository record

  17. Identification of MMS22 as a regulator of DNA repair

    Duro, ErisUniversity of Dundee2010

    Obstacles such as DNA damage can block the progression of DNA replication forks. This is a major source of genome instability that can lead to cell transformation or death. The budding yeast MMS1 and MMS22 genes were identified in a screen for mutants that were hypersensitive to DNA alkylation that …

    dundee Repository record

  18. THE ROLE OF DNA REPAIR IN DNA METHYLATION DYNAMICS

    Gould, Poppy AeronUniversity of Cambridge2018

    … involves the erasure and re-establishment of DNA methylation by both passive and active mechanisms, including DNA repair pathways, and occurs concurrently with an increase in developmental potency. In addition to Uhrf1 and the Tet enzymes, the interplay between activation induced cytidine …

    cambridge Repository record

  19. Cdk12 regulates DNA repair Genes by suppressing intronic polyadenylation

    Dubbury, Sara JaneMassachusetts Institute of Technology2018

    … relatively specifically, suppressing the HR DNA damage repair pathway and sensitizing cells to genotoxic stresses that cause replication fork collapse, such as Parp1 inhibitors. The proposed role for Cdk12 in regulating HR is clinically significant for two reasons. First, Cdk12 …

    mit Repository record

  20. DNA Repair Mechanisms, Aflatoxin B1-Induced DNA Damage and Carcinogenesis

    Mulder, Jeanne Elizabeh2013

    … thesis investigated the relationship between DNA repair mechanisms, aflatoxin B1 (AFB1)-induced DNA damage and carcinogenesis. Mice deficient in 8-oxoguanine glycosylase (OGG1, the rate-limiting enzyme in repair of oxidized guanine), mice heterozygous for OGG1, and wild type mice, were exposed …

    queens Repository record

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