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Showing 1 to 6 of 6 for “"DNA polymerase beta"”.
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The Isolation and Partial Purification of DNA Polymerase-Beta from Soybean
… to those previously determined for animal polymerase-beta. Therefore, since the structure of polymerase-beta shows significant evolutionary conservation in both plant and animal species and given strong functional correlations among species, polymerase-beta performs a vital role in plants …
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DNA polymerase beta inhibitor pamoic acid : toxicity to metakaryotic human cancer stem cells (HT-29)
… and tumor growth, use a peculiar mode of DNA synthesis and segregation that involves inter alia expression of large amounts of RNA polymerase beta during DNA synthesis. It was hypothesized that an inhibitor of DNA polymerase beta would be toxic to metakaryotic stem cells at concentrations …
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The Choreography of Base Excision Repair
The DNA in each cell of the human body is damaged more than 10,000 times every day. To avoid the mutagenic and cytotoxic effects that can be caused by the accumulation of DNA damage, human cells utilize DNA repair pathways such as base excision repair (BER). BER is carried out by a series of DNA …
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Arsenic in drinking water caused ultra-structural damage in urinary bladder but did not affect expression of DNA damage repair genes or repair of DNA damage in transitional cells
… carcinogenesis/cocarcinogenesis is inhibition of DNA damage repair. In laboratory animals, urinary bladder transitional cell carcinoma has only been observed in dimethylarsinic acid [DMA(V)]-exposed F344 rats. The goal of the present studies was to investigate inhibition of DNA repair as a mode of …
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Base excision repair, folate deficiency and cancer
… deficiency has been reported to incapacitate DNA repair pathways and thereby affect the genomic stability. Our lab has reported previously and here again through this research that folate deficiency affects the DNA damage inducibility of base excision repair pathway. Our study shows the …
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Effect Of Dietary Folate Restriction On Colon Carcinogenesis In Dna Polymerase β Haploinsufficient Mice
… (WT) animals, as did a BER deficiency in DNA polymerase Β haploinsufficient (Β-pol+/-) mice exposed to 1, 2-dimethylhydrazine (DMH), a known colon and liver carcinogen. We combined both folate restriction and a BER deficiency to determine the fate of colon tissue after exposure to DMH. Of …