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Showing 1 to 2 of 2 for “"DNA polymerase ζ"”.
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Disruption of Dna Polymerase Zeta Promotes An Innate Immune Response
<p>DNA polymerase ζ (pol ζ) is a specialized polymerase that protects cells from the consequences of DNA damage and stress. Without pol ζ function mammalian cells and yeast are exquisitely sensitive to genotoxic stresses including ultraviolet irradiation and platinum compounds such as the …
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The Molecular Mechanism of Break Induced Replication
DNA double strand break (DSB) is one of the most threatening of all types of DNA damages as it leads to a complete breakage of the chromosome. The cell has evolved several mechanisms to repair DSBs, one of which is break-induced replication (BIR). BIR repair of DSBs occurs through invasion of one …