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Showing 1 to 15 of 15 for “"DNA oxidation"”.
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Genomic consequences of DNA oxidation by peroxynitrite
… of damaging a variety of biomolecules, including DNA. Of the four nucleobases of DNA, guanine has the lowest oxidation potential and thus considerable attention has been given to the study of the oxidation of this base by peroxynitrite. A variety of DNA lesions are generated from guanine including …
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Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage.
… analog rutin are complex structures. Using a DNA oxidation/cleavage assay, flavone reduces DNA nicking by 91%. Depending on the solvent system used, quercetin can either increase or decrease DNA oxidation. Rutin exhibits neither pro- nor antioxidant activity. The molecular interactions …
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NEW METHODS FOR DETECTING BIOMARKERS OF OXIDATIVE STRESS AND REDOX SIGNALING ON PROTEIN CYSTEINE RESIDUES
… redox-based signaling occurs is reversible oxidation of cysteine residues in the presence of low concentrations of these oxidants. S-Nitrosothiols (RSNO) and sulfenic acids (RSOH) are thought to be two of the most common cysteine modifications, and formation of these species reversibly …
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Binding study of nickel complex to protein by equilibrium dialysis
… of square planar nickel complexes in promoting DNA oxidation. This complex was synthesized and its structure was proven by electrospray mass spectroscopy, H-NMR, and elemental analysis. The H-NMR data also demonstrated that this complex has two vacant coordination sites in the distorted …
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Oxidative DNA-Schädigung durch elektronisch angeregte Carbonylverbindungen und daraus gebildete Radikalspezies
… Acetophenonderivate durch dG, 8-oxodG, DNA, molekularen Sauerstoff und die Ketone selbst bestimmt. Für AP-OAc, AP und BP wurden Triplettlebensdauern von 7-9 µs gemessen, während die Triplettzustände von AP-OH und AP-OtBu aufgrund alpha Spaltung deutlich kurzlebiger waren (ca. 1 µs); die …
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Effects of Long-term Strenuous Exercise on Oxidative DNA Damage and Proteinuria in Humans
… of long-term strenuous exercise on oxidative DNA damage and proteinuria in trained individuals. In the first project, four successive triathlons accompanied by long-term training in a triathlete was chosen as the experimental design and procedure. In the second project, repeated 5-h bouts of …
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Effects of Long-term Strenuous Exercise on Oxidative DNA Damage and Proteinuria in Humans
… of long-term strenuous exercise on oxidative DNA damage and proteinuria in trained individuals. In the first project, four successive triathlons accompanied by long-term training in a triathlete was chosen as the experimental design and procedure. In the second project, repeated 5-h bouts of …
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Differences of DNA-Transcription Factor Interactions Following Chromium Exposure
… of 8-oxoguanine in the consensus sequence of êB DNA on the binding affinity of p50BD was determined using a 22-mer and a 30-mer double-stranded DNA oligonucleotide containing the NF-êB binding site. The addition of a carboxyl moiety at position 8 on guanine (creating 8-oxoguanine) was observed to …
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Differences of DNA-Transcription Factor Interactions Following Chromium Exposure
… of 8-oxoguanine in the consensus sequence of êB DNA on the binding affinity of p50BD was determined using a 22-mer and a 30-mer double-stranded DNA oligonucleotide containing the NF-êB binding site. The addition of a carboxyl moiety at position 8 on guanine (creating 8-oxoguanine) was observed to …
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Synthesis and detection of dna damage
The biological effects of DNA alkyl adducts are difficult to evaluate at the cellular level due to their instability. Synthesis of oligonucleotides that contain a single N7-alkylguanine has become a vital tool to achieve the above goal. However, the instability of N7-alkyguanines is not compatible …
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REPAIR AND EFFECTS OF THE 8-OXOG LESION IN DNA
Eukaryotic DNA is packaged in a condensed state with histone proteins. The minimal structural unit within packaged eukaryotic DNA is the nucleosome core particle (NCP). The NCP consists of a 146 bp DNA fragment wrapped around an octamer of histone core proteins. Nucleosome core particle formation …
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REPAIR AND EFFECTS OF THE 8-OXOG LESION IN DNA
Eukaryotic DNA is packaged in a condensed state with histone proteins. The minimal structural unit within packaged eukaryotic DNA is the nucleosome core particle (NCP). The NCP consists of a 146 bp DNA fragment wrapped around an octamer of histone core proteins. Nucleosome core particle formation …
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Investigation of the Role of Groove Hydration and Charged Nucleosides in DNA Charge Transfer
Structural analyses of DNA oligonucleotides indicate the presence of bound water molecules in the major and minor grooves of DNA. These water molecules participate in DNA charge transfer by their reaction with guanosine radical cation to form 7,8-dihydro-8-oxo-guanine (8-oxoG), which when treated …
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The dynamic interplay between DNA damage and metabolism : the metabolic fate and transport of DNA lesions and novel DNA damage derived from intermediary metabolism
… two novel and complementary facets of endogenous DNA damage: the development of biomarkers of inflammation based on metabolites of DNA damage products and the formation of DNA adducts by electrophilic products of intermediary metabolism. From the first perspective, endogenous DNA damage generated …
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Nitrosative guanosine deamination : pyrimidine ring opening implications of effects in homogeneous solution as well as anisotropic environments
… to cause two types of chemical reactions with DNA bases, deamination and interstrand cross linking involving the nitrosation of exocyclic amino group of guanine, adenine and cytosine. The ingestion or inhalation of nitrosating reagents (NO[subscript x][superscript -] ) contained in foods, or …