Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"DNA nanostructures"”.
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Transport properties of DNA nanostructures
Besides the role of genetic information storage, DNA has been proposed as a new material in nanotechnology. The idea came from the nature-occurring Holliday junction (HJ) which allows more than 2 DNA strands to be assembled. Multiple HJs can be combined with desired orientation to form complex 2- …
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Nanopore-Based Readout of Encoded DNA Nanostructures
… a single molecule composed of a double strand of DNA. As the strand threads through the nanopore, attachments produce secondary peaks in the already reduced current. The ability to encode information in modification sequences and self-assemble designed strands through DNA nanotechnology opens up …
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Nanopore-based Protein Sensing with DNA Nanostructures
… drives electrically charged molecules, like DNA, through the nanopore. As molecules move through the pore, the liquid containing the salt ions is displaced. The drop in liquid volume in the nanopore correlates to an increase in resistance and thus a drop in current. This current drop can …
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Crystalline frameworks self-assembled from amphiphilic DNA nanostructures
… wide range of potential chemical modifications, DNA nanotechnology is now regarded as a prime route for the bottom up fabrication of nanostructured materials. However, current approaches to the formation of designed 3D DNA crystals are complicated by the difficulties in designing sub-units able …
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Synthesis of oligonucleotide analogues for use in DNA nanostructures
… through selective base-pair recognition, DNA is a<br/>unique material for orderly self-assembled construction at the nanoscale. To develop a<br/>nanotechnology platform on a grid of addressable molecular building blocks using DNA<br/>node structures, DNA complexes need to be fixed onto …
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A computational model for the isothermal assembly of tiled DNA nanostructures
Complex DNA nanostructures have proven difficult to assemble from starting materials. Inefficient nanostructure assembly constitutes a barrier to the widespread use of DNA nanotechnology and is difficult to investigate experimentally due to the complicated nature of the assembly. This work …
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DNA Three-way Junctions as Scaffolds for Hybrid Catalysis
… to catalysis is essential. Bio-functionalised DNA is known to catalyse a number of industrially important chemical reactions, and DNA supported catalysts have the advantage of being biodegradable and non-toxic, and are therefore of interest as green alternatives to traditional chemical …
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Programmable biomolecular integration and dynamic behavior of DNA-based systems for development of biomedical nano-devices
… role as a carrier of genetic information, DNA has emerged as an engineering material for construction of nano-devices. The advances in the field of DNA nanotechnology have enabled design and synthesis of DNA nanostructures of arbitrary shapes and manipulation of the nanostructures' …
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A synthetic lipid scramblase built from DNA
The programmable self-assembly facilitated by DNA nanotechnology provides unparalleled capabilities to construct functional devices at the nanoscale. Recently, DNA nanostructures have been developed to interact with biological membranes and serve as artificial counterparts of natural ion channels, …
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Designing 3D Wireframe DNA Nanoparticles for Programmable Innate Immune Activation
DNA nanotechnology harnesses the predictability and specificity of canonical base pairing interactions to enable the synthesis of complex DNA nanodevices capable of interacting with their environment in a controllable manner. Wireframe DNA origami are a class of highly customizable DNA …
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DNA nanotechnology for light-emitting plasmonic applications
DNA nanotechnology for light-emitting plasmonic applications - Sara Rocchetti. The development of plasmonic nanocavities allows for the direct observation of light-matter interactions at the nanoscale. Collective oscillations of electrons (SPPs) at a metal-dielectric interface confine light into …
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DNA based networks, nanostructures, and meta-stable states
… important materials is deoxyribonucleic acid (DNA). DNA has several unique properties that make it a good candidate for nanotechnology research. The primary aim of this research is to use DNA three-way junctions as building blocks and to assemble them into a huge DNA networks through self …
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Self-assembly of three-dimensional nucleic acid nanostructures
… material and its structure. While a diversity of DNA nanostructures have been designed by specifying complementarity rules between strands, creation of 3D nanostructures requires careful design of strand architecture, and patterns are often limited to a volume of 25 x 25 x 25 nm³ Here, we address …
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Investigating the interaction of a metallosupra molecular cylinder with nucleic acids
… is also discussed. Besides, being a drug target, DNA can be used as material for constructing beautiful architectures. Examples of these DNA nanostructures are presented. In Chapter 2, three way junction recognition by a metallocylinder is shown to occur not only in DNA but also in RNA. The …
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Multi-Level Coarse-Grained Modelling on DNA Functionalised Building Blocks
DNA nanotechnology has proliferated in recent years as investigators have increasingly harnessed the selectivity of DNA base pairing to form multitudes of diverse structures, with a wide range of applications. The stiffness of the double-strand DNA (dsDNA) with a persistence length of around 50nm …
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Designer DNA Condensates: From Multiphase Architectures to Synthetic Exosome Release
… intricate organisation of molecular components. DNA nanotechnology and synthetic biology allow the construction of programmable model systems that reduce complexity in a controlled manner, enabling targeted investigation and rational design. By leveraging the programmability of nucleic acids, it …
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DNA-Based Mimics of Membrane Proteins Lipid-DNA Interactions Determine Function
Nucleic acids, particularly DNA, are used as a nanoscale building material, due to their unique controllability via complementarity of base pairing. One of the potential applications of DNA nanotechnology is creating synthetic constructs mimicking function of membrane proteins. These natural …
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DNA-based Artificial Mimics of Cell-surface Machinery
… hosted by their biological counterparts. DNA nanotechnology has emerged as a prime route for biomimicry given its yet unparalleled control over the structure and dynamic responses of synthetic nanostructures. Particularly promising in the context of bottom-up synthetic biology is the …
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DNA Canvas: Towards affordable and scalable enzymatic fabrication of DNA nanoarrays
In biological systems, DNA serves as a carrier of hereditary information, facilitated by predictable and programmable base-pairing rules. The field of DNA nanotechnology takes the DNA molecule out of its original context and using the same set of rules to construct complex structures and molecular …
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Structural and functional complexity in synthetic cells from amphiphilic DNA nanostars
… highly programmable and predictable nature of DNA hybridisation has been exploited to develop DNA nanostructures for use as building blocks, with cholesterol-terminated DNA nanostars being one example. These amphiphilic structures, named C-stars, have been shown to self-assemble through …
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