Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"DNA minor groove"”.
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Exploring the dynamic landscape of small molecule-DNA binding
Deoxyribonucleic acid (DNA) is a fundamental component in all living organisms found in Nature. Although both the double-helix structure of this biomolecule and the fact that it stores all the genetic information required by the organism to survive are well understood there are still aspects …
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Two -Photon Standing Wave Fluorescence Photobleaching With Application to the Study of Chromatin Motion
… nuclei. The chromatin is labeled using the DNA minor groove binding dye Hoechst 33342 or GFP labeled histone H2B. The diffusion is highly constrained and cannot be observed in a standard, single beam fluorescence recovery after photobleaching experiment. To determine the chemical origin of …
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Pharmacological characterisation of selected pyrrolobenzodiazepines as anti-cancer agents. Pharmacokinetic and pharmacodynamic characterisation of the pyrrolobenzodiazepine dimer SJG-136 and the monomers D709119, MMY-SJG and SJG-303
… shown to have cytotoxic activity with predicted DNA sequence selectivity. Research focused upon the PBD dimer, SJG-136, selected for clinical trials, and the novel PBD monomer compounds D709119, MMY-SJG and SJG-303. SJG-136, a novel sequence-selective DNA minor groove cross-linking agent, was …
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Functional divergence of the RNA polymerase II transcription machinery in Plasmodium falciparum
… the biochemical characterisation of protein-DNA interactions, protein-protein interactions and the biomolecular condensation properties of these transcription factors, this study aimed to provide insight into the molecular mechanisms governing promoter recognition and the regulated assembly …
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Identification of determinants of sensitivity to duocarmycin analogues: A class of potent anti-cancer drugs
… (MOA) of duocarmycins has been elucidated as DNA minor groove alkylation, not much is known about the factors involved in the intrinsic sensitivity of cancer cells to duocarmycins. This thesis aims to identify the determinants of sensitivity of duocarmycin analogues by utilising three …
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Interaction of Bacteriophage Mu Middle Transcription Activator Protein Mor with Promoter DNA
… make base</p> <p>specific interactions in the DNA minor groove.</p> <p>2. To identify the bases between -30 and -57 of the promoter Pm that are important</p> <p>for its function, in terms of binding to His-Mor and transactivation with</p> <p>interactions with RNAP subunits, thus optimizing the …