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Showing 1 to 1 of 1 for “"DNA methyltransferase ; specificity ; base flipping"”.
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A directed evolution design of target specificity and kinetic analysis of conformational transitions in the HhaI methyltransferase /
DNA cytosine-5 methyltransferases (MTases) recognize short DNA sequences and catalyze the transfer of the methyl group from the cofactor AdoMet to the C5-position of a target cytosine. In this work both these aspects of the MTase mechanism have been addressed. First, using rational protein design …