Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"DNA methylation profiling"”.
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Diagnostic and prognostic DNA methylation biomarkers of renal clear cell carcinoma /
… current study aimed to develop a gene-specific DNA methylation tool for non-invasive and early kidney cancer diagnosis and follow-up. Genome-wide DNA methylation profiling utilizing microarrays allowed the identification of a set of novel presumable ccRCC-specific DNA methylation biomarkers, …
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The DNA methylation landscape of metastatic prostate cancer: from characterization to liquid biopsy applications
… role in tumorigenesis and evolution. The role of DNA methylation has been particularly elusive in this context. While this epigenetic mark has been extensively profiled in healthy and cancerous samples, our ability to understand its relationship with underlying biological processes is still …
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PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS
… (PRC2) components. This complex catalyzes the trimethylation of Lysine 27 on histone 3 (H3K27me3), thereby repressing transcription during embryonic development. However, our understanding of how PRC2 dysfunction affects cortical development, and how WVS heterozygous mutations impact H3K27 …
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Social-Demographics, Health Behaviors, Telomere Length In Mexican-American Cohort and Circulating Dna Methylation In Bladder Cancer
… with age (r=-0.15, p</p> <p><strong>II. METHYLATION IN SERUM CELL-FREE DNA AND CPG-SNP WITH BLADDER CANCER RISK</strong></p> <p>Epigenetic alterations are early events of cancers, including bladder cancer. In the present study, we aimed to examine methylation profiles of circulating DNA …
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The Placenta Methylome: Novel Insights into DNA Modifications in the Human Placenta
The DNA methylation profile of the placenta is unique as compared to other somatic tissues and is marked by global hypomethylation. The placental methylome has been shown to modulate developmental processes, intrauterine exposures, and placental function. However, the precise mechanisms underlying …
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The Epigenetics of Small Cell Prostate Cancer
… (MCAM) we identified distinctly hypermethylated DNA sequences present in AR<sup>-</sup>SCPC but not in AR<sup>+</sup>ADENO xenografts. Interestingly, we observed a low frequency of AR promoter methylation found in samples that lacked AR expression despite previous publications, which led to …