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Showing 1 to 2 of 2 for “"DNA interstrand crosslink repair"”.
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
<p>DNA interstrand crosslink (ICL) repair is vital for cellular proliferation and survival. Defects in the repair of DNA crosslinks have been associated with congenital abnormalities, bone marrow and kidney failure, liver dysfunction, and cancer. DNA nucleases play a significant role during the …
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New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… threat to every species, and therefore robust DNA damage repair mechanisms have evolved to protect against genotoxic threats. FANCD2 and FANCI associated nuclease 1 (FAN1) has roles in protection against two major threats to genomic stability: DNA interstrand crosslinks (ICLs), and the …