Global ETD Search
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Showing 1 to 2 of 2 for “"DNA interstrand crosslink (ICL)"”.
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
<p>DNA interstrand crosslink (ICL) repair is vital for cellular proliferation and survival. Defects in the repair of DNA crosslinks have been associated with congenital abnormalities, bone marrow and kidney failure, liver dysfunction, and cancer. DNA nucleases play a significant role during the …
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Fancm and Faap24 Maintain Genomic Stability Through Cooperative and Unique Functions
… derived from FA patients is hypersensitivity to DNA interstrand crosslinking agents such as mitomycin C (MMC) and cisplatin, suggesting that FA- and FA-associated proteins play important roles in protecting cells from DNA interstrand crosslink (ICL) damage. Two genes involved in the FA pathway, …