Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"DNA interfaces"”.
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Engineered synthetic translational control for next generation mRNA gene therapies
… gene and cell therapy. Unlike their synthetic DNA counterparts, synthetic mRNA has an increased safety profile due to its transient gene expression and ability to express outside of the nucleus. Furthermore, it can be more easily delivered to cells via entry only into the cytoplasm. While …
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Multiscale Modeling of Biomolecular Complexes
… method to model complexes between protein and DNA that contain looped or coiled DNA. The approach combines a coarse-grained model of the DNA loop, based on the classical theory of elasticity, with an atomic model of proteins and protein-DNA interfaces based on molecular dynamics. The method is …
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DNA Biosensors Based on Gold-Coated Magnetic Nanoparticles
The interaction between DNA-functionalized surfaces/nanoparticles and free oligonucleotides in solution is the foundation of many devices such as DNA gene chips, therapeutic devices, and DNA biosensors. Electrochemical transduction provides a convenient means for studying DNA hybridization due to …