Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"DNA interactions"”.
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Structural Studies of Hmg-D-Dna Interactions
… all of which share the HMG domain, a small DNA-binding structural motif. HMG1/2 proteins interact directly with nucleosomes, modulate chromatin structure, and modulate the activation of gene expression by a number of transcriptional activators. The structure of HMG-D bound to linear duplex …
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Protein/DNA interactions during site-specific recombination
… of the tyrosine recombinase family. Previous DNase I footprinting experiments demonstrated that IntDOT interacts with five arm-type sites, but exactly how the arm-type sites participate in the integration and excision of CTnDOT was not known. I constructed site-directed mutations in each of …
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Predicting and understanding inter-locus DNA interactions
Most computational methods analyze DNA as a linear sequence of information when in fact the 3D architecture and organization contains important structural and functional elements that provide valuable information on DNA's role in mediating cellular processes. However, this 3D conformation has been …
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Synthesis, DNA interactions and activation of novel cytotoxic anthraquinones.
… to be mediated through its interaction with DNA and the DNA processing enzyme, topoisomerase II. Hence, an investigation of the DNA binding properties of mitoxantrone and related bis-substituted alkylaminoanthraquinones was undertaken with a view to developing agents with reduced toxicity to …
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Computational Methods for the Measurement of Protein-DNA Interactions
It is of interest to know where in the genome DNA binding proteins act in order to effect their gene regulatory function. For many sequence specific DNA binding proteins we plan to predict the location of their action by having a model of their affinity to short DNA sequences. Existing and new …
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Dynamics of protein-DNA interactions in a Mu transpososome
… allows movement of a defined stretch of DNA, a transposon, from one DNA location to another. This process is required for the life-cycles of many viruses, from bacteriophage Mu to HIV; it is spreading antibiotic resistances between bacterial populations; and it is responsible for …
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The effect of supercoiling on small molecule-DNA interactions
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1998.
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Dithioated Phosphates in DNA Duplex Thermodynamics and Protein-DNA Interactions
Phosphorodithioated DNA contains sulfur atoms at both non-bridging phosphoryl oxygen positions. As an achiral chemical modification of the internucleotide linkage it imparts altered biophysical properties to the phosphate moiety, but still retains normal DNA characteristics such as the ability to …
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On mass spectrometry analysis of gene regulatory protein-DNA interactions
Contains fulltext : 194868.pdf (Publisher’s version ) (Open Access)
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The Role of Water-Adenine Complexes in Protein-Dna Interactions
… investigate the role of specific water-mediated interactions in protein-DNA complexes. The analogues create a ""bound"" water molecule that will be distinct from the water molecules of bulk solvent."
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High-resolution NMR spectroscopic analysis of anticancer drugs, DNA and their interactions: 1. Platinum anticancer compounds - DNA interactions. 2. Anthracycline drugs - DNA interactions and modified DNA
… The exploitation of the stereochemical interactions between anticancer drugs and DNA is of great importance for the ultimate clinical advances of cancer chemotherapy, which needs the detailed structural knowledge of DNA, drugs, and their interactions. Cisplatin is one of the most …
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Single molecule studies of ligand-DNA interactions using atomic force microscopy
… binding of various ligands with dsDNA via the mechanism of intercalation, principally using the technique of atomic force microscopy (AFM). Since the description of the first AFM in the mid 1980’s, AFM has emerged as a sensitive and versatile analytical tool, capable both of …
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A study of DNA-DNA interactions during bacteriophage lambda integrative recombination
… recombination system was used to study DNA-DNA interactions during site-specific recombination in bacteriophage lambda. Oligodeoxynucleotides 28 bases long containing either the top strand or the bottom strand sequences of the bacterial attachment site (attB) with or without base …
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Recognition, stability, and assembly in protein folding and protein-DNA interactions
A detailed understanding of the fundamental forces and mechanism which determine biomolecular structure and function is crucial to utilizing proteins and nucleic acids as therapeutic agents, as research tools, and in industrial and environmental applications. To elucidate the principles of …
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DNA-Based Mimics of Membrane Proteins Lipid-DNA Interactions Determine Function
Nucleic acids, particularly DNA, are used as a nanoscale building material, due to their unique controllability via complementarity of base pairing. One of the potential applications of DNA nanotechnology is creating synthetic constructs mimicking function of membrane proteins. These natural …
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Structural and biochemical studies of Oct-1 POU domain-DNA interactions
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Application of the Theory of Elasticity to Modeling of Protein -Dna Interactions
… to modeling the conformations and energetics of DNA loops is presented. The model is based on the classical theory of elasticity, modified to describe the intrinsic twist and curvature of DNA, the DNA bending anisotropy, and electrostatic properties. All the model parameters are considered to be …
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Computational Inference of Genome-Wide Protein-DNA Interactions Using High-Throughput Genomic Data
… techniques have been invented to map these interactions genome-wide, including ChIP-based methods (ChIP-chip, ChIP-seq, etc.), nuclease digestion methods (DNase-seq, MNase-seq, etc.), and others. However, a single experimental technique often only provides partial and noisy information about …
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