Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"DNA hybrids"”.
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RNA-binding Proteins and RNA-DNA Hybrids Regulate Repetitive DNA Stability in Health and Disease
… to proper cellular function. Repetitive DNA sequences, such as the ribosomal DNA repeats (rDNA) and transposons, represent a large portion of eukaryotic genomes. Due to their repetitive nature, these loci are prone to aberrant recombination. In fact, rDNA repeat instability and increased …
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Investigating the interaction of a metallosupra molecular cylinder with nucleic acids
… is also discussed. Besides, being a drug target, DNA can be used as material for constructing beautiful architectures. Examples of these DNA nanostructures are presented. In Chapter 2, three way junction recognition by a metallocylinder is shown to occur not only in DNA but also in RNA. The …
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Ribonuclease H2, RNA:DNA hybrids and innate immunity
… the cell results in an accumulation of RNA:DNA hybrids. To investigate the immunostimulatory potential of such substrates, RNA:DNA hybrids with different physiochemical properties were designed and synthesised. Methods to purify the hybrids from other contaminating nucleic acid species were …