Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"DNA flexibility"”.
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Temperature and sequence dependence of DNA flexibility
DNA fragments shorter than the persistence length display about five orders of magnitude higher flexibility than predictions of the semi-flexible polymer models based on its persistence length. Via single molecule cyclization assays, flexibility of different constructs at various conditions can be …
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Regulation of nucleosome dynamics
… called nucleosomes, where 147 base pairs of DNA are wrapped around a protein core. Stable packing of DNA in nucleosomes imposes a barrier for accessibility of genetic code on DNA for replication, transcription, and repair. The dynamics of nucleosomal DNA provide a mean for gene regulation by …
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STUDYING THE INTERACTION OF CANCER AND THROMBOSIS THERAPEUTICS WITH PROTEIN AND DNA
… of therapeutics. Many cancer drugs bind to DNA and inhibit replication. We have AFM and simulations, based on the worm-like chain model (WLC), to study DNA conformational changes due to its interaction with two cancer drugs, cisplatin and Pt-Acramtu. We found that cisplatin induces a 36º …
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Molecular Modeling: Elucidation of Structure/Function Relationships of Proteins and DNA at the Atomic Resolution
… of our analyses provide information about DNA flexibility and packaging, internal migration of ligands in a small protein, and substrate specificity of an enzyme system.