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Showing 1 to 14 of 14 for “"DNA enzymes"”.
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Synthetic coenzymes for in vitro selection of DNA enzymes.
… a number of catalytically active single-stranded DNA molecules (deoxyribozymes) have been isolated from combinatorial libraries (pools) of randomized oligonucleotides. These enzyme-like DNAs customarily utilize divalent metal ions as cofactors in their catalysis. The metal ion cofactors are …
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DNA enzymes for peptide-nucleic acid conjugation and for lysine methylation
Proteins and RNA are known to be enzymes in nature. These biopolymers have complex secondary and tertiary structures that can enable substrate binding and catalysis. DNA is primarily double-stranded and is not known to be catalytic in nature. However, given the similarities in chemical structure …
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Catalysis by DNA enzymes: roles of lanthanide(III) ions and DNA aptamer modules
For many years scientists considered DNA and RNA to be merely the means for the storage and transmission of genetic information. Catalytic roles of some RNA molecules, called ribozymes, were discovered in the early 1980s. Considering structural similarities between RNA and DNA, it was reasonable to …
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DNA enzymes for tyrosine PEGylation and azido-adenylylation of peptide and protein substrates
Proteins and RNA are used as enzymes in nature, while DNA is used for the storage and transfer of genetic information. Proteins and RNA are biopolymers that can fold into complex secondary and tertiary structures to enable substrate binding and catalysis. Given the structural similarity to RNA, …
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In Vitro Selection of Highly Efficient DNA Enzymes as RNA Nucleases and Metal Biosensors
… nM. This system represents the first example of DNA-based biosensor for metal ions. Similar approaches can be applied to develop deoxyribozymes that can probe other metal ions and at various concentration ranges.
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SILOXANE-CONTAINING PHOSPHOLIPIDS AS POTENTIAL DRUG DELIVERY SYSTEMS
… based on biomolecules such as peptides, DNA, enzymes etc., with the aim of improving or optimising the potency of these biomolecules. Liposomes are colloidal vesicles derived from amphiphilic phospholipid biomolecules and have the capacity to encapsulate a broad spectrum of molecules. The …
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DNA catalysts as phosphatases and as phosphoserine lyases
… that have catalytic roles in nature, whereas DNA is primarily considered to store and transfer genetic information. However, artificial single-stranded DNA has been identified by in vitro selection to catalyze several chemical reactions and several of those are of biological relevance. For in …
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DNA catalysts for amide bond cleavage and for lysine side chain modification
… is known to exploit both proteins and RNA as enzymes. No natural enzymes, however, have been discovered that are made of DNA. One can think of both RNA and proteins as large biopolymers with the potential to form complex secondary and tertiary structures capable of doing catalysis. Given the …
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Deoxyribozymes for peptide substrates: exploring the landscape of nucleophiles and electrophiles
While DNA is most familiar in its double-stranded form as a storehouse of genetic information, its chemical similarities to naturally occurring ribozymes suggest that it can act as a catalyst. Single-stranded DNA molecules that have the ability to catalyze various bioorganic reactions are called …
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Kinase deoxyribozymes
… has developed the use of proteins and RNA as enzymes, while DNA is used for the storage and transfer of genetic information. Proteins and RNA are biopolymers that can fold into specific secondary and tertiary structures to enable catalysis. Considering the structural similarity to RNA, …
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In vitro selection of deoxyribozymes for O-glycoside cleavage and for 3-nitrotyrosine modification
… and perform catalysis in nature. Single-stranded DNA is structurally similar to RNA and is also capable of catalytic function. DNA enzymes, or deoxyribozymes, are not known to exist in nature, but they have been identified in lab by in vitro selection for a variety of chemical reactions. De novo …
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Nucleobase-modified deoxyribozymes for amide and peptide hydrolysis
Nature has evolved proteins and RNA as enzymes. These biopolymers can fold into complex structures to enable catalysis. DNA is primarily double-stranded and is non-catalytic in nature. However, considering the structural similarity to RNA, single-stranded DNA should also be able to form complex …
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In vitro selection of monovalent metal ion-dependent DNAzymes
DNA is no longer thought of as only the purveyor of genetic information, but also as a highly programmable and functional biopolymer. It was discovered in 1994 that some single-stranded DNA sequences can fold into complex tertiary structures to catalyze reactions, these DNA sequences are called …
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Purification of Elongation Factor 2 From Wheat Germ
No abstract prepared.