Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 229 for “"DNA damage response"”.
-
UHRF1 and the DNA Damage Response
Our DNA is under constant threat from endogenous and exogenous damaging agents. Our cells have evolved a network of signaling pathways and repair mechanisms that detect and counteract this threat, collectively referred to as the DNA damage response. Cells that lose the ability to cope with DNA …
-
Molecular pathways controlling DNA damage response
… is activated after cells are exposed to the DNA damage and depending on diverse conditions and type of DNA damage, p53 upregulation could lead to repression of the cell cycle progression and induction of apoptosis. Consequently, the p53 protein is considered vital to cancer progression and …
-
The DNA damage response to ATR inhibition
… protein kinase ATR is an apical regulator of the DNA damage response and coordinates DNA repair, cell cycle checkpoint engagement, and DNA replication to ensure genome stability. To achieve this, ATR signalling often cooperates with, or antagonises, other DNA repair pathways, including many known …
-
The interaction of CtIP with DNA damage response proteins
… in vivo with, and directly binds to, the DNA damage mediator proteins containing BRCT domains: 53BP1, MDC1, TopBP1 and NBS1. The binding sites on all of these proteins have been mapped establishing which regions of CtlP interact directly with 53BP1, MDC1, TopBP1 and NBS1 and vice versa. …
-
Focused CRISPR-Cas9 screens investigating the DNA damage response
The DNA damage response (DDR) consists of a complex network of interconnected pathways which detect and repair damaged DNA, maintaining genome integrity. Somatic mutations in DDR genes are associated with tumour development, while germline mutations cause a spectrum of disorders ranging from …
-
Targeting the DNA damage response in hormone-driven cancers
… (BC) and prostate cancer (PCa). Defects in the DNA damage response (DDR) as well as replication stress are responsible, in part, for driving genomic instability and accumulation of DNA damage. While the resulting alterations can be beneficial for tumour development and progression, it also …
-
Investigating the DNA damage response induced by Typhoid Toxin
… from where it enters bystander cells and causes DNA damage through its putative nickase activity. Purified typhoid toxin causes typhoid fever symptoms and mortality in animal models, and in animal infection models the toxin facilitates chronic infections by Salmonella. However, it is neither …
-
Identifying a role for Ciz1 in the DNA damage response
In proliferating cells, cell cycle arrest and DNA repair are induced upon detection of DNA damage. The DNA damage response (DDR) to double strand DNA breaks is mediated by phosphatidylinositol 3-kinase-like protein kinases (PIKKs), which propagate DDR signalling by phosphorylating SQ/TQ motifs in …
-
Tyrosine 370 Phosphorylation of Atm Positively Regulates Dna Damage Response
<p>Ataxia telangiectasia-mutated (ATM) mediates DNA damage response by controlling irradiation (IR)-induced foci formation, cell cycle checkpoint, and apoptosis. However, how upstream signaling regulates ATM is not completely understood. Here, we show that upon IR stimulation, ATM associates with …
-
The role of UBZ1 in PCNA-dependent DNA damage response
… frequently must deal with several sources of damage that can alter the cell's genomic material. DNA damage can be caused by exogenous agents, like radiation and toxins or by endogenous factors, like Reactive Oxygen Species (ROS), produced during normal oxygen metabolism. in order to guarantee …
-
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
… steps and proteins involved with removal of damaged DNA from the genome are well characterised. However, the source of DNA damage for which these pathways have evolved to counteract remains unclear in many instances. Many of these pathways are also compensatory and have complex relationships …
-
Establishing the role of RNF4 in the vertebrate DNA damage response
… elevated mutation rates, sensitivity to DNA damaging agents and also demonstrated synthetic lethality with other DNA repair genes. Although the role of vertebrate RNF4 in the DNA damage response was not yet established, it could rescue the Schizosaccaromyces pombe STUbL mutant phenotypes, …
-
Mechanisms and consequences of DNA damage, response and apoptosis in spermatozoa.
DNA damage in spermatozoa is a crucial contributor to spontaneous abortion, severe genetic disease in the offspring and infertility. The chromatin of spermatozoa is highly compacted, transcriptionally and translationally silent, hence lacking DNA damage response (DDR). DDR foci follow within …
-
Mechanisms and consequences of DNA damage, response and apoptosis in spermatozoa.
DNA damage in spermatozoa is a crucial contributor to spontaneous abortion, severe genetic disease in the offspring and infertility. The chromatin of spermatozoa is highly compacted, transcriptionally and translationally silent, hence lacking DNA damage response (DDR). DDR foci follow within …
-
Targeting the DNA damage response protein ATR kinase in pancreatic cancer
Therapeutic targeting of the DNA damage response (DDR), coupled with the implementation of personalised treatment strategies, has the potential to improve the poor survival outcomes of pancreatic ductal adenocarcinoma (PDAC). Many common genetic alterations in PDAC augment replication-associated …
-
A study of inter-individual differences in the DNA damage response
Agents that damage our DNA are omnipresent in our environment and inside our cells themselves. Left unrepaired, DNA damage can lead to premature aging, neurodegeneration and cancer. Humans have thus evolved intricate and widespread mechanisms to repair and manage this damage. These …
-
Identification of Epstein-Barr virus proteins that inhibit the DNA damage response
… EBV is known to manipulate the cellular DNA damage response (DDR). To date there have only been a few studies on the interplay between EBV and the DDR and the functions of many EBV proteins remain uncharacterized. In this study, we screened a library of 47 EBV proteins for the ability to …
-
The synthetic dosage lethality between hTERT and DNA damage response associated genes
… entire tumor, leading to suboptimal treatment responses. Consequently, it is of paramount importance to identify common characteristics of cancer cells that are absent in non-cancerous cells. 85-90% of primary cancer cells overexpress hTERT. Under normal conditions, the expression of this gene …
-
Characterisation of CIP29 : a potential target of the eukaryotic DNA damage response
… ortholog of CIP29, XCip29, is phosphorylated in response to DNA double strand breaks (DSBs). This phosphorylation was shown to be dependent on the activity of ATM, one of the three PI3KK kinases that orchestrate the DNA damage response (DDR). The purpose of our research was to investigate the …
-
The role of the BARD1 BRCT domains in the DNA damage response
The DNA within a cell is damaged on a continuous basis by both endogenous and exogenous agents. One of the most dangerous types of damage a cell can incur are DNA Double stranded breaks (DSBs) as failure to repair these types of lesions can lead to mutations, cell death and cancer. In order to …
Page 1 of 12