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Showing 1 to 20 of 121 for “"DNA damage repair"”.
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Effect of TIS21 on DNA Damage Repair Induced by Etoposide
… was induced during chemotherapy-mediated DNA damage in cancer cells, a role of TIS21/BTG2/PC3 in DNA repair process remains to be elucidated. In this study, the mechanism and role of TIS21 involved in eotposide induced DNA damage signaling were examined. H2AX foci formation, …
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Identification and Investigation of Novel DNA Damage Repair Genes Via Network Analysis
While most DNA lesions are repaired faithfully and without genotoxic effect, double-stranded breaks (DSBs) are exceptional. The deleterious potential of a misrepaired DSB represents a severe threat to cellular integrity. Repair machinery defects are frequently observed in tumorigenic and oncogenic …
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The functional and molecular characterisation of the novel DNA damage repair protein Bod1L
DNA damage induces MDC1 recruitment and establishes a signalling platform that mediates the DNA damage response (DDR). I show that Bod1L plays a central role in DDR by controlling MDC1 and PP2A-B56 localisation to damaged DNA. Bod1L depletion leads to micronuclei formation in undamaged cells and …
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Evaluating Chemical Crosslinking as a Tool for Enhancing DNA Damage Repair Interactome Analysis
Eukaryotic cells can repair DNA Double-Strand Breaks (DSBs) through a number of mechanisms, including end resection-mediated pathways and non-homologous end joining (NHEJ). An End-Bridging Complex (EBC) comprised of elements from both end resection and NHEJ may be the first complex recruited to DSB …
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Novel Structures of RAD51 Reveal Mechanisms in DNA Damage Repair and Genomic Stability
… of genomic stability by promoting the repair of DNA double-strand breaks and the protection of DNA replication forks. RAD51 functions alongside the tumour suppressor protein BRCA2 to catalyse DNA strand-exchange reactions which form an integral part of Homology-Directed Repair. RAD51 …
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More evidence for H2O2-mediated oxidative stress in vitiligo-increased epidermal DNA damage / repair.
… under H2O2-mediated oxidative stress, oxidative DNA damage would be highly expected. This thesis shows for the first time that epidermal 8-oxoG levels as well as plasma level of this oxidised DNA base are significantly increased in patients compared to healthy controls. We have shown that …
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MICROGRAVITY NEGATIVELY AFFECTS DNA DAMAGE REPAIR AND THE ANTI-LEUKEMIC FUNCTION OF HUMAN NATURAL KILLER CELLS
… high-energy nuclei component of GCR) induces DNA damage, alters HSC function/differentiative capacity, and triggers leukemogenesis when these cells repopulate murine hosts. Importantly, astronaut on missions beyond low-Earth orbit are exposed to these unique high-energy species of radiation …
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Analyzing Genomic Studies and a Screen for Genes that Suppress Information Loss During DNA Damage Repair
… with the competition between different DNA damage responses. DNA is continuously damaged and imperfect repair can have extremely detrimental effects. Double strand breaks are the most severe form of damage and can be repaired in several different ways or countered by other cellular …
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SOX2 is Associated with Changes in DNA Damage Repair and Cell Cycle Gene Expression and Regulates E2F1
… to evade treatment is through alterations in DNA damage repair pathways. Currently, the tumor expression profiles score for homologous recombination deficiency is available for patients. However, this is typically only used to determine if Poly (ADP-Ribose) Polymerase (PARP) inhibitors are an …
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The impact of chronic loss of STAG2 on DNA damage repair and the epigenome in acute myeloid leukaemia
… the 3D genome, controlling gene expression and DNA repair. The consequences of a STAG2 mutation on Cohesin function is not well understood and in particular, the effects on DNA damage repair remain to be fully elucidated. In addition, it is likely that the epigenome is affected by Cohesin’s …
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The Role of Bacteroides Conjugative Transposons in the Spread of Antibiotic Resistance Genes, And, The Role of recA in DNA Damage Repair in Deincoccus Radiodurans
… We have identified a 7-kilobase segment of DNA, located on a Bacteroides conjugative transposon (CTnBST), that carries a gene for erythromycin resistance (ermB). The same DNA sequence (100% identical) had been previously identified in the genome of Arcanobacterium pyogenes, a gram positive …
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Arsenic in drinking water caused ultra-structural damage in urinary bladder but did not affect expression of DNA damage repair genes or repair of DNA damage in transitional cells
… carcinogenesis/cocarcinogenesis is inhibition of DNA damage repair. In laboratory animals, urinary bladder transitional cell carcinoma has only been observed in dimethylarsinic acid [DMA(V)]-exposed F344 rats. The goal of the present studies was to investigate inhibition of DNA repair as a mode of …
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Structural Insights into the Mechanisms Controlling the Modification and the Readout of Histone H3.1
… processes such as transcription, replication and DNA damage repair mechanisms. These marks can be reversibly deposited by specialized "writer" domains in chromatin remodelling enzymes. Similarly, histone PTMs are recognized by "reader" domains which aid in coordinating appropriate responses and …
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In-depth bioinformatics analysis of the phosphoproteome of triple negative breast cancer treated with a tumor selective NQO1 bioactivatable drug
… species (ROS) in the process, which causes DNA lesions in cancer cells. The status of NQO1 is important for the IB-DNQ mediated cancer cell death. IB-DNQ mediated therapy has great potency in killing breast cancer cells compared to PARP inhibitor Rucaparib. From this proteomics study, large …
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Enhancing Radiation Sensitivity In Non-Small Cell Lung Cancer
… cancer cells to radiation through attenuating DNA damage repair through attenuating DNA damage repair and accentuating G2-M cell cycle arrest. However, when combined with chemoradiation <em>in vivo</em>, ganetespib has variable effects on different cells. For radiation sensitization through MEK …
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Taxotere suppresses breast cancer growth through inducing lincRNA-p21 expression
… and chemotherapy. This induction contributes to DNA-damage repair, cell death and cell cycle regulation. In this study, we focused on Taxotere (TXT) mediated chemotherapy of breast cancer cells and found that lincRNA-p21 is robotically induced upon TXT treatment. Secondly, we observed increased …
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Discovery of Novel Ubiquitin- and Methylation-Dependent Interactions Using Protein Domain Microarrays
… in distinct transcription regulation and DNA damage repair pathways, likely mediated by specific "reader" proteins. There are only two H2Aub1-specific readers identified and no known H2Bub1-specific readers. Using a ubiquitin-binding domain microarray, I discovered the phospholipase …
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Study of the DNA Damage Complexes Within the HTLV-1 Tax Oncoprotein Interactome
… instability via repression of the cellular DNA damage repair response. Our laboratory has previously shown that the interaction between Tax and various proteins involved in the DNA-damage response pathway impairs the ability of these proteins to mount an efficient repair response. As part of …
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Interplay between an integrative and conjugative element and its bacterial host
… gene transfer, introducing large fragments of DNA. Often, MGEs contain cargo genes beneficial to the host, conferring new traits such as antibiotic resistances, pathogenicity, and metabolic capabilities. Though MGEs sometimes carry beneficial genes, they can impose fitness costs on their host. …
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High-throughput screening for ADP-ribosyl hydrolase 3 inhibitors
… (PAR) signaling is an important component of DNA damage repair, DNA replication, and initiation of parthanatos, a method of controlled cell death. While PAR has been well studied for decades, much is still unknown about PAR’s initiation of parthanatos and the importance of mono(ADP-ribose) …
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