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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"DNA damage and repair"”.
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DNA damage and repair during the mammalian hormonal cycle
… of this study was to determine the pattern of DNA damage and repair during the mammalian female hormonal cycle. This was done to determine whether the hormonal cycle must be taken into account when DNA damage and repair studies are done in female subjects, especially so when surrogate tissue …
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Hydrogen peroxide -dependent and -independent DNA damage and repair
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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INVESTIGATIONS OF DNA DAMAGE AND REPAIR IN THE HUMAN LENS
… healthcare budgets. Developing a greater understanding of the underlying causes could lead to potential therapies or preventative treatments being elucidated. Oxidative stress is a key factor in the formation of cataract, of which one consequence is DNA damage. The current study investigates the …
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Quantifying the pro- and antimutagenic roles of DNA damage and repair
… challenged by a multitude of endogenous and exogenous mutagenic factors such as environmental exposures or replication errors. Therefore, evolution has supplied cells with a number of repair mechanisms to protect their genetic information; however, excessive exposures or defects in the …
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Investigation into the role of DNA damage and repair during influenza infection and inflammation
The DNA in every cell accrues nearly 100,000 lesions daily from both endogenous and exogenous sources. The accumulated damage, e.g. strand breaks and base lesions, can lead to mutations, cell death, and cancer if not repaired efficiently. To protect genome integrity, organisms have evolved multiple …
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Analysis of DNA damage and repair responses in cerium exposed cells and hepatocyte spheroids
… exposures, including airborne particulates and industrial chemicals, have long been known to impact public health and safety by contributing to the risk of developing cancer. One key concern is a chemical's potential to induce DNA damage, as damage can lead to the formation of mutations that …
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Engineering a single cell microarray platform for high throughput DNA damage and repair analysis
DNA damage contributes to cancer, aging, and heritable diseases. Ironically, DNA damaging agents are also commonly used in current cancer treatment. We therefore need robust, high throughput, and inexpensive tools for objective, quantitative DNA damage analysis. The single cell gel electrophoresis …
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The use of alkaline gel electrophoresis to analyze hydrogen peroxide-caused DNA damage and repair in Escherichia coli
… oxygen such as hydrogen peroxide cause single-strand breaks in DNA. Most of the methods for estimating such breakage and subsequent repair are designed for eucaryotic cells and methods for use with bacteria are needed. Accordingly, a method based on alkaline gel electrophoresis of DNA was …
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Creation and enhancement of a quantized hybrid computational model of cell cycle progression including DNA damage and repair mechanisms
… predict biological responses to external stimuli and influencing experimental setup. Modelling has been successfully used to investigate cell growth of both cancer and healthy cells. The modelling of cancer development and treatment response have delivered patient benefit with respect to radiation …
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A Comparison of Two 'In Vitro' Assays to Assess Radiosensitivity in Patients Receiving Radiotherapy
… thesis addresses the occurrence of normal tissue damage as a limiting factor in curative radiotherapy and the need for predictive radiosensitivity testing. Patients who display unusual sensitivity to radiation may also exhibit a poor DNA repair capacity. Consequently, in vitro assays which assess …
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Actions of Pi3K-Delta Inhibitor, Idelalisib, and Its Combination With Bendamustine In Chronic Lymphocytic Leukemia
… phosphatidylinositol 3-kinase isoforms (α, β, δ, and γ) play a major role in cancer cell growth and survival. PI3K α and β are most studied. PI3K pathway is highly dysregulated in many cancers and aberrant PI3K signaling is associated with oncogene mutations and disease progression in solid tumors …
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Applications of a novel assay to investigate variation in DNA repair in human populations.
The aim was to develop and optimise an assay for assessing DNA repair in human lymphocytes and to use this assay in population studies. DNA repair has not been studied extensively in human populations due to the difficulty of finding a suitable assay for its measurement. This thesis describes the …
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Engineering a comet-based platform for specific, sensitive, and high throughput assessment of multiple DNA repair pathways in humans
… to dangerous genotoxins is unavoidable, as DNA damaging agents are ubiquitous both in our environment and within our cells. The diversity in lesions induced by these agents led to the evolution of several DNA repair pathways that suppress the mutagenic and toxic effects of DNA damage. …
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INFLAMMATION INDUCED CYTOSINE DEAMINATION DAMAGE IN CANCER ETIOLOGY
Cancer is a major health challenge worldwide, and inflammation is thought to be an important factor in cancer etiology. The mutational landscape of human cancer is dominated by cytosine to thymine transition mutations, and the primary mechanism for these mutations is the deamination of cytosine and …
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A Novel Drug Delivery System Incorporates a Functional Composite Scaffold Derived from Taxifolin with Potential Cytotoxic and Anticancer Effects on Triple Negative Breast Cancer
… (TNBC) is characterised by its aggressive nature and poor prognosis. This study examines the anticancer properties of the flavonoid taxifolin and its cytotoxic and genotoxic effects on triple-negative breast cancer (TNBC) and blood cells from healthy individuals and breast cancer patients. Central …
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A Novel Drug Delivery System Incorporates a Functional Composite Scaffold Derived from Taxifolin with Potential Cytotoxic and Anticancer Effects on Triple Negative Breast Cancer
… (TNBC) is characterised by its aggressive nature and poor prognosis. This study examines the anticancer properties of the flavonoid taxifolin and its cytotoxic and genotoxic effects on triple-negative breast cancer (TNBC) and blood cells from healthy individuals and breast cancer patients. Central …
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Effects of Radiation Exposure on Lung Carcinogenesis
… the most prevalent forms of cancer in both men and women with over 1.3 million annual related deaths worldwide. Analysis of several human populations exposed to radiation reveals that the lung is remarkably susceptible to the carcinogenic effects of radiation exposure. The considerable lung …
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XPC Haplotypes Alter DNA Repair Capacity and Levels of Genetic Damage
… group C (XPC) is the key recognition factor of DNA damage in global genome nucleotide excision repair (NER). The disease Xeroderma pigmentosum (XP) results from mutations leading to structural defects of the encoding gene and in some instances trace to changes in a single nucleotide. The XPC …
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Space radiation-induced bystander signaling in 2D and 3D skin tissue models
… hazard to astronauts on long-duration missions, and the low fluences of charged particles characteristic of this field suggest that bystander effects, the phenomenon in which a greater number of cells exhibit damage than expected based on the number of cells traversed by radiation, could be …
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