Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1006 for “"DNA damage"”.
-
UHRF1 and the DNA Damage Response
Our DNA is under constant threat from endogenous and exogenous damaging agents. Our cells have evolved a network of signaling pathways and repair mechanisms that detect and counteract this threat, collectively referred to as the DNA damage response. Cells that lose the ability to cope with DNA …
-
Molecular pathways controlling DNA damage response
… is activated after cells are exposed to the DNA damage and depending on diverse conditions and type of DNA damage, p53 upregulation could lead to repression of the cell cycle progression and induction of apoptosis. Consequently, the p53 protein is considered vital to cancer progression and …
-
Molecular Recognition At Dna Damage Sites
… distinctive complexes by facilitating error-free DNA repair via homologous recombination (HR) mechanism. The particular focus of this dissertation is the BRCA1-RAP80 ubiquitin recognition complex, which is composed of five core constituents (RAP80, Abraxas, MERIT40, BRCC45, and BRCC36) and targets …
-
Synthesis and detection of dna damage
The biological effects of DNA alkyl adducts are difficult to evaluate at the cellular level due to their instability. Synthesis of oligonucleotides that contain a single N7-alkylguanine has become a vital tool to achieve the above goal. However, the instability of N7-alkyguanines is not compatible …
-
DNA Damage responses in plant stem cells
… escape environmental hazards, which induce DNA damage and cause mutations. Plants are also subject to DNA damage caused by endogenous processes such as transposon movement. Plant stem cell populations in particular must be protected from genotoxicity, as they are the origin of all organs, …
-
The DNA damage response to ATR inhibition
… protein kinase ATR is an apical regulator of the DNA damage response and coordinates DNA repair, cell cycle checkpoint engagement, and DNA replication to ensure genome stability. To achieve this, ATR signalling often cooperates with, or antagonises, other DNA repair pathways, including many known …
-
Micropatterned cell arrays for detecting DNA damage
Numerous agents are capable of interacting with DNA and damaging it. Permanent changes in the DNA structure can be both mutagenic and cytotoxic; therefore, methods to measure the susceptibility of cells to mutations are important for risk assessment and identifying therapeutic interventions. One …
-
HPV16 E6* Induces Oxidative Stress and DNA Damage
… oxidative stress led to higher levels of DNA damage. The observed increase in ROS may be due to a decrease in cellular anti-oxidant activity, as we found that E6* expression also led to decreased expression of SOD and Gpx, These studies indicate that E6* may play an important role in …
-
E2F1 induction following DNA damage and oncogene activation
… of E2F1 are described that are induced following DNA damage via mechanism(s) not previously identified. In addition, data are presented which show that E1A expression not only deregulates E2F1, but also elevates E2F1 levels. E1A is dependent on interaction with RB protein to induce E2F1 levels and …
-
DNA damage and repair during the mammalian hormonal cycle
… of this study was to determine the pattern of DNA damage and repair during the mammalian female hormonal cycle. This was done to determine whether the hormonal cycle must be taken into account when DNA damage and repair studies are done in female subjects, especially so when surrogate tissue …
-
The AMPK signalling pathway in cancer and DNA damage
… suggested a role for AMPK in the response to DNA damage, produced by treatments such as ionising radiation and the anti-cancer drug etoposide. However, the molecular mechanism underlying this activation was unclear. This thesis shows that etoposide activates AMPK in a CaMKKβ-dependent manner …
-
The interaction of CtIP with DNA damage response proteins
… in vivo with, and directly binds to, the DNA damage mediator proteins containing BRCT domains: 53BP1, MDC1, TopBP1 and NBS1. The binding sites on all of these proteins have been mapped establishing which regions of CtlP interact directly with 53BP1, MDC1, TopBP1 and NBS1 and vice versa. …
-
Mechanisms of monohalogenated acetic acid induced genomic DNA damage
… that monoHAAs were directly alkylating DNA was tested and rejected when no damage accumulated in acellular DNA. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was investigated as a possible molecular target for the monoHAAs; each of the monoHAAs inhibited GAPDH with variable efficacy. …
-
Hydrogen peroxide -dependent and -independent DNA damage and repair
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
-
Focused CRISPR-Cas9 screens investigating the DNA damage response
The DNA damage response (DDR) consists of a complex network of interconnected pathways which detect and repair damaged DNA, maintaining genome integrity. Somatic mutations in DDR genes are associated with tumour development, while germline mutations cause a spectrum of disorders ranging from …
-
Targeting the DNA damage response in hormone-driven cancers
… (BC) and prostate cancer (PCa). Defects in the DNA damage response (DDR) as well as replication stress are responsible, in part, for driving genomic instability and accumulation of DNA damage. While the resulting alterations can be beneficial for tumour development and progression, it also …
-
Investigating the DNA damage response induced by Typhoid Toxin
… from where it enters bystander cells and causes DNA damage through its putative nickase activity. Purified typhoid toxin causes typhoid fever symptoms and mortality in animal models, and in animal infection models the toxin facilitates chronic infections by Salmonella. However, it is neither …
Page 1 of 51