Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"DNA copy number variations"”.
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Bayesian Hidden Markov Models for finding DNA Copy Number Changes from SNP Genotyping Arrays
DNA copy number variations (CNVs), which involve the deletion or duplication of subchromosomal segments of the genome, have become a focus of genetics research. This dissertation develops Bayesian HMMs for finding CNVs from single nucleotide polymorphism (SNP) arrays. A Bayesian framework to …
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Integrated Genomics Of Susceptiblity To Therapy-Related Leukemia
… are enriched in genes involved in cell cycle and DNA repair, suggesting that these processes play a role in susceptibility. By integrating gene expression and genetic information we prioritized network nodes for experimental validation as contributors to expression networks and t-AML …
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An ensemble based approach for drug sensitivity prediction
… on various aspects of regulation including DNA copy number variations, gene expression, DNA methylation and protein abundance. To extract relevant information from the various data types, we applied a Random Forests based approach to generate sensitivity predictions from each type of data …
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Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma
Genomic diversity and adaptive plasticity of melanoma tumors limit durable control with conventional and targeted therapies. Nevertheless, pathological activation of the ERK1/2 regulatory system is a linchpin tumorigenic mechanism associated with the majority of both primary and recurrent disease. …
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High resolution DNA copy number analysis of constitutional chromosomal aberrations in human genomic disorders
… (5-10 Mb), it was anticipated that a significant number of submicroscopic deletions or duplications (DNA copy number variations, CNV) were overlooked in patients with idiopathic mental retardation with or without congenital anomalies. This thesis represents one of the _rst exhaustive studies of …