Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"DNA copy number"”.
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Computational Analysis of Genome-Wide DNA Copy Number Changes
DNA copy number change is an important form of structural variation in human genome. Somatic copy number alterations (CNAs) can cause over expression of oncogenes and loss of tumor suppressor genes in tumorigenesis. Recent development of SNP array technology has facilitated studies on copy number …
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Mitochondrial DNA Copy Number, Insulinemic Potential of Lifestyle, and Colorectal Cancer
… an independent genome, i.e., mitochondrial DNA (mtDNA). It has been increasingly recognized that mtDNA copy number (mtDNAcn) is a biomarker for mitochondrial function and cellular oxidative stress. To date, the few studies that have assessed associations between mtDNAcn and CRC outcomes have …
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Identification of DNA Copy Number-Dependent Transcriptional Deregulation inHepatocellular Carcinoma (HCC)
… genomic profiles analysis, in which the genomic copy numbers and gene expression profiles are analyzed by the integrative way to define the chromosomal regions with both genomic copy number variation and concomitant transcriptional deregulation, is posited to provide a promising strategy to …
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Bayesian Hidden Markov Models for finding DNA Copy Number Changes from SNP Genotyping Arrays
DNA copy number variations (CNVs), which involve the deletion or duplication of subchromosomal segments of the genome, have become a focus of genetics research. This dissertation develops Bayesian HMMs for finding CNVs from single nucleotide polymorphism (SNP) arrays. A Bayesian framework to …
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High resolution DNA copy number analysis of constitutional chromosomal aberrations in human genomic disorders
… (5-10 Mb), it was anticipated that a significant number of submicroscopic deletions or duplications (DNA copy number variations, CNV) were overlooked in patients with idiopathic mental retardation with or without congenital anomalies. This thesis represents one of the _rst exhaustive studies of …
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MITOCHONDRIAL DNA COPY NUMBER AND AUTOPHAGY IN THE AGING BRAIN AND IN AN ALZHEIMER MOUSE MODEL
… mice. To answer these questions, mitochondrial DNA (mtDNA), TFAM (transcription factor A mitochondrial) and two stages in autophagy, autophagosomal formation and degradation were measured in the hippocampus/cortex of non-transgenic (non-Tg) and the APP(Swe, DI)/NOS2-/- AD mouse model (AD-Tg) …
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Phenotypic and transcriptomic consequences of ribosomal DNA copy number variation in Caenorhabditis elegans and Saccharomyces cerevisiae
Ribosomal DNA (rDNA) forms the template for mature ribosomal RNA (rRNA) and shows considerable sequence conservation through evolution. In eukaryotic genomes rDNA is present in one or more tandem repeat arrays, with copy number variation (CNV) commonly observed in inter- and intra-species …
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Hidden Markov Model inference copy number change in array-CGH data
… resulting in genomic changes involving DNA copy number gains or losses. Identifying the genomic location of these regional alterations provides important opportunities for the discovery of potential novel oncogenes and tumor suppressors. Recently, array based competitive genomic …
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Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up
… (HCC) prognosis by integrative analysis of DNA copy number aberrations (CNAs) and gene expression profiles. Array comparative genomic hybridization and expression array were performed on 45 and 31 HCC samples, respectively. To identify functionally important genes, concordant results of DNA …
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Molecular analysis of herpes simplex virus type 1 latency in experimentally infected mice / Barry Slobedman.
… whether latent HSV genomes are a result of viral DNA amplification in the PNS during the establishment phase and to investigate the relationship between HSV DNA copy number and viral transcriptional activity during latent infection of the PNS. In order to map the distribution of viral nucleic acid …
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Differential Dependency Network and Data Integration for Detecting Network Rewiring and Biomarkers
… tasks. In the case of detecting somatic DNA copy number aberrations using bulk tumor samples in cancer research, normal cell contamination becomes one significant confounding factor that weakens the power regardless of whichever methods used for detection. To address this problem, we …
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Modeling and Characterization of Dynamic Changes in Biological Systems from Multi-platform Genomic Data
… technologies such as gene expression and and copy number microarrays provide ample opportunities to study cellular activities at the individual gene and network levels. The aim of this dissertation is to formulate mathematically dynamic changes in biological networks and DNA copy numbers, to …
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Detection and Characterization of Multilevel Genomic Patterns
DNA microarray has become a powerful tool in genetics, molecular biology, and biomedical research. DNA microarray can be used for measuring the genotypes, structural changes, and gene expressions of human genomes. Detection and characterization of multilevel, high-throughput microarray genomic data …
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Genomic analysis of mouse tumorigenesis
… Microarray Analysis (ROMA) for tumor DNA copy number asessment and single nucleotide polymorphism (SNP) genotyping using the SNaPshotM system (Applied Biosystems) to detect loss of heterozygosity (LOH) in mouse tumors. The murine version of ROMA was tested on DNA from early-stage …
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Autism Spectrum Disorder and Mitochondrial Dysfunction: The Role of Mitochondrial Dynamics
… MTT and ATP assays. Transmission electron microscopy (TEM), using cryogenic techniques, was used to examine mitochondrial morphology by measuring nine parameters: area, area2 , form factor, area-weighted form factor, aspect ratio, perimeter, circularity, Feret's diameter and roundness. TEM images …
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The Effect of Mitochondrial Dynamics on Cell Cycle Progression
… and analyzed for the changes in mitochondrial DNA copy number and mitochondrial mass. We found that mitochondria mass gradually increased from G1 phase to mitotic phase and reduced back at the returning G1 phase. However, mtTFA, NRF-1, PRC, known as transcriptional factors regulating …
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Mitochondrial function in atherosclerosis and vascular smooth muscle cells
… in the Western world. Although mitochondrial DNA (mtDNA) damage has been implicated in atherosclerosis, it is unclear whether the damage is sufficient to impair mitochondrial respiration, and mitochondrial dysfunction has not been demonstrated. Treatment of vascular smooth muscle cells (VSMCs) …
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Investigating the Effects of Markers of Biological Stress on the Association between Adverse Childhood Experiences and Central Artery Stiffness
… stress—telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Here, the potential effects of TL and mtDNAcn on the association between ACEs and central artery stiffness were examined. It was hypothesized that TL and/or mtDNAcn would be associated with both ACEs and central artery …
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