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Showing 1 to 7 of 7 for “"DNA catalyst"”.
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ENZYME-LIKE DNA CATALYST DESIGN
This work develops DNA as a programmable chiral platform for asymmetric catalysis in water. It first reviews the promise and limitations of DNA-based catalysis: although DNA offers chirality, structural programmability, aqueous compatibility, and sustainability, existing systems are often limited …
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DNA-catalyzed covalent modification of amino acid side chains in tethered and free peptide substrates
… a close analog of RNA, the catalytic ability of DNA was evaluated and the first artificial DNA catalyst (deoxyribozyme) discovered in 1994. Since then, deoxyribozymes have been shown to catalyze a wide variety of chemical reactions, including phosphodiester bond cleavage, nucleic acid ligation, …
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Kinase deoxyribozymes
… the use of proteins and RNA as enzymes, while DNA is used for the storage and transfer of genetic information. Proteins and RNA are biopolymers that can fold into specific secondary and tertiary structures to enable catalysis. Considering the structural similarity to RNA, single-stranded DNA …
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DNA Three-way Junctions as Scaffolds for Hybrid Catalysis
… As part of this, the development of novel catalysts and new approaches to catalysis is essential. Bio-functionalised DNA is known to catalyse a number of industrially important chemical reactions, and DNA supported catalysts have the advantage of being biodegradable and non-toxic, and are …
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DNA catalysts for amide bond cleavage and for lysine side chain modification
… however, have been discovered that are made of DNA. One can think of both RNA and proteins as large biopolymers with the potential to form complex secondary and tertiary structures capable of doing catalysis. Given the structural similarities between RNA and DNA, it is reasonable to think that …
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DNA catalysts as phosphatases and as phosphoserine lyases
… that have catalytic roles in nature, whereas DNA is primarily considered to store and transfer genetic information. However, artificial single-stranded DNA has been identified by in vitro selection to catalyze several chemical reactions and several of those are of biological relevance. For in …
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Deoxyribozymes for peptide substrates: exploring the landscape of nucleophiles and electrophiles
While DNA is most familiar in its double-stranded form as a storehouse of genetic information, its chemical similarities to naturally occurring ribozymes suggest that it can act as a catalyst. Single-stranded DNA molecules that have the ability to catalyze various bioorganic reactions are called …