Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"DNA adducts"”.
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Deoxyribose oxidation chemistry and endogenous DNA adducts
… a variety of electrophiles that react with DNA produce cytotoxic and mutagenic adducts. One source of such electrophiles is deoxyribose in DNA itself. Oxidation of each position in deoxyribose generates a unique spectrum of products, many of which are highly reactive with DNA bases and lead …
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DNA adducts as molecular biomarkers of exposure to benzo(a)pyrene
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1997.
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Cisplatin in yeast--repair of DNA adducts and binding of HMG domain proteins
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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Characterization of cyclopenta[cd]pyrene-DNA adducts in vitro and in mice in vivo
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1996.
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Comparison of DNA adducts in mouse bladder and lung tissue from smoke-exposed and control mice
… the cigarette smoke may lead to the formation of DNA adducts within body tissues. DNA adducts arise from the covalent bond formed between a carcinogenic chemical and DNA. An increase in the number of DNA adducts present in a tissue could indicate the initiation of the carcinogenesis process. The …
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Specific binding of human SRY (Sex-Determining Region Y) to DNA adducts of the anticancer drug cisplatin
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.
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Investigation of the mechanism of mutagenesis by the DNA adducts of the human bladder carcinogen, 4-aminobiphenyl
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1992.
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The Effect of Ethanol and Acetaldehyde on Formation and Repair of Carcinogen-Dna Adducts in the Mammary Gland
… acetaldehyde are capable of enhancing carcinogen-DNA adduct formation and inhibiting removal. However, these effects are dependent on the concentrations of ethanol or acetaldehyde, the time of exposure and the dose of carcinogen. Additionally, these effects, particularly those related to adduct …
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Novel genotoxins that target estrogen receptor- and androgen receptor- positive cancers : identification of DNA adducts, pharmacokinetics, and mechanism
… reasoned that the potential genotoxic effect of DNA adducts would be increased in target cells if these adducts were camouflaged by their association with receptor proteins. This association could shield the DNA adducts from repair proteins and thus increase the toxicity towards a tumor cell. …
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Studies on the detection of nucleotides and oligonucleotides by mass spectrometry
… and modified nucleotides such as DNA adducts by mass spectrometry. DNA adducts are important because they are formed during chemical carcinogenesis as well as during anti-cancer chemotherapy. However, DNA adducts are not routinely monitored due to difficulties associated with their …
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Mechanisms of toxicity and carcinogenicity of three alkylanilines
… Understanding the metabolic activation of and DNA adduct formation by these chemicals is an important first step in elucidating their mechanisms of carcinogenesis and toxicity. Cytochrome P450-mediated metabolism was profiled based on the hypothesis that N-hydroxylated metabolites are critical …
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C8-Arylguanine Modified Hairpin Oligonucleotides: Synthesis, Conformational Analysis, and Tools for the Investigation of Z-DNA Formation
Z-DNA is the only DNA conformation that has a left-handed helical twist. Z-DNA has been implicated in carcinogenesis from its role in gene expression. Z-DNA formation has been linked to mutagenesis since it may play a role in genetic instability and can induce gene deletions. However, the specific …
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Biological Consequences Of Complex Dna Lesions Induced By Bis-Electrophiles
Genomic DNA is constantly modified by bis–electrophiles which induce a wide array of DNA adducts. DNA adducts can threaten cell viability and genomic integrity by interfering with DNA replication and transcription. Unless repaired, they can be misread by DNA polymerases, leading to heritable …
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Molecular Dosimetry Studies of Forward Mutation Induced at the YG2 Locus in Maize by Ethyl Methanesulfonate
… mutation and the level of covalently bound ethyl DNA adducts were determined. Prepared kernels were treated for 8 h at 20$\sp\circ$C with 1 to 10 mM EMS. EMS yielded a concentration-dependent increase in mutation induction proportional to the exposure concentration. The kinetics of mutation …
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New methodologies for studying the biological activity of platinum complexes
… were evaluated based on their ability to form DNA adducts that bind specifically to HMG-domain proteins. A mixture of platinum amino acid complexes was prepared and combined with DNA to form platinum adducts, some of which were recognized by HMG1 in a gel shift assay. In order to identify the …
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Plant Activation of Bicyclic Aromatic Amines, Benzidine and 4-Aminobiphenyl
… of plant- and mammalain-activated benzidine DNA adducts were induced from plant-activated benzidine in S. typhimurium and analyzed using $\sp{32}$P-postlabelmg and HPLC. Mammalian- and plant-activate benzidine metabolites induced DNA adducts in bacteria. To determine the genotoxicity of …
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The plant-activation of m-phenylenediamine and its mutagenic, biochemical and molecular characterization
… plant-activated m-PDA metabolites. The genomic DNA was analyzed using the $\sp{32}$P-postlabeling method. DNA adducts were quantified using an ion-pairing reversed-phase HPLC. The data demonstrated that m-PDA metabolites covalently adducted to deoxyribonucleotides in the genome of tester strain …
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