Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"DNA Virus"”.
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Sensing Foreign DNA: The Role of DNA-PKcs in Human Anti-viral Innate Immunity
… patterns (PAMPs), such as viral genomic DNA, which is a major PAMP during DNA virus infection. Viral DNA sensing leads to the activation of the STING-TBK1-IRF3 signalling axis and the production of type I interferon. Previously, our work identified the non-homologous end-joining protein …
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Effect of viral and host genetics on pcv2 replication in lymphoblasts and clearance by monocytes
Porcine circovirus type 2 (PCV2), a very small, circular, single-stranded DNA virus, is the major etiologic agent of porcine circovirus-associated diseases (PCVADs) and is widely prevalent in swine herds. It causes significant economic losses to the global pig industry. Three major PCV2 genotypes …
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Purification and Characterization of Simian Virus 40 Large T Antigen
Simian Virus 40 is a small DNA virus which can replicate normally following productive infection of permissive monkey cells, transform various cell lines of different species in tissure culture, and induce tumor formation following injection into newborn hamsters. Large T antigen is one of two …
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Disease in Spheniscus penguins: Feather-loss disorder and Avian Pox
… Avian pox is an enveloped doublestranded DNA virus that is mechanically transmitted via arthropod vectors or mucosal membrane contact with infectious particles or birds. Avian pox outbreaks primarily affected chicks, often resulted in death, and were not associated with handling, rainfall, …
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Role BK polyomaviru v lidských nádorech
BK polyomavirus (BKV) je malý neobalený ubikvitně rozšířený DNA virus, který u imunosuprimovaných jedinců může způsobovat závažná onemocnění, konkrétně BK polyomavirovou nefropatii (BKVaN) a hemoragickou cystitidu. Mimo toho se o BKV uvažuje jako o možném původci některých nádorových onemocnění u …
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Seroprevalence of parvovirus B19 in blood donors at the Kitwe Central Hospital, Blood Bank, Kitwe, Zambia
Human Parvovirus (B19V) is a small, single-stranded, non-enveloped DNA virus which is pathogenic to humans causing a wide array of clinical complications which include erythema infectiosum, aplastic crisis and hydrops foetalis. It is generally harmless in healthy individuals but may be life …
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Seroprevalence of parvovirus B19 in blood donors at the Kitwe Central Hospital, Blood Bank, Kitwe, Zambia
Human Parvovirus (B19V) is a small, single-stranded, non-enveloped DNA virus which is pathogenic to humans causing a wide array of clinical complications which include erythema infectiosum, aplastic crisis and hydrops foetalis. It is generally harmless in healthy individuals but may be life …
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Molecular Study of the B19 (Human) Pathogenic Parvovirus
<p>The B19 (human) parvovirus is a small single stranded DNA virus of 5.4 kilobases. B19 is specific for erythroid progenitor cells and has been propagated in vitro only with human erythroid bone marrow. Replication of viral DNA and the viral protein products of B19 appear similar to those of other …
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Molecular Breeding of Porcine Circovirus Type 2 by Synthetic DNA Shuffling
Porcine circovirus type 2 (PCV2) is a small, non-enveloped, single-stranded DNA virus that causes disease in pigs and is an economically important pathogen affecting pig populations worldwide. PCV2 contains two major open reading frames (ORF): ORF1 encodes two replicase proteins and ORF2 encodes …
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The Roles Of Human Cytomegalovirus Tegument Proteins Pul48 And Pul103 During Lytic Infection
<p>THE ROLES OF HUMAN CYTOMEGALOVIRUS TEGUMENT PROTEINS pUL48 AND pUL103 DURING LYTIC INFECTION</p> <p>by</p> <p>DANIEL A. ORTIZ</p> <p>December 2015</p> <p>Advisor: Dr. Philip E. Pellett</p> <p>Major: Immunology and Microbiology</p> <p>Degree: Doctor of Philosophy </p> <p> Human cytomegalovirus …
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An examination of the role of IFI16 in detecting viral DNA in human immortalised keratinocytes
The presence of exogenous DNA in the cytosol results in the activation of the DNA sensor cyclic GMP-AMP synthase (cGAS). cGAS produces the second messenger cyclic GMP-AMP (cGAMP) which binds to and activates the endoplasmic reticulum adapter STimulator of INterferon Genes (STING). Activated STING …
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Examining the risk factors for hepatitis B infection among pregnant women attending antenatal care in Kunene region, a case control study
… B is a viral infection caused by Hepatitis B virus (HBV) which is a double stranded DNA virus, a member of the Hepadnavidae family of viruses. World Health Organization estimates that about 257 million people are living with Hepatitis B virus infection. Namibia has a high prevalence of …
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Innate Immune Sensing and Signaling of Cytosolic DNA
In eukaryotic cells, DNA is normally confined within the nucleus and mitochondria. DNA exposed in the cytosol is a danger signal that warns the host of invading microbial pathogens and triggers innate immune responses including the production of type-I interferons (IFNs). Endogenous DNA that is …
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Protein-mediated nanocrystal assembly for floating gate flash memory fabrication
… Nowadays using bio-nano techniques such as DNA, virus or protein for NC synthesis and assembly has become a hot topic and feasible for actual electronic device fabrication. In this dissertation a new method for NC deposition wherein a colloidal suspension of commercially-available NCs was …
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Viral and cellular proteins involved in vaccinia virus egress
Vaccinia virus (VACV) is a large double-stranded DNA virus with a cytoplasmic site of replication. It has a complex life cycle that produces two distinct infectious virion forms, Intracellular Mature Virions (IMVs) and Extracellular Enveloped Virions (EEVs). The host cell microtubule trafficking …
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Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus, often acquired during childhood, that currently infects more than 50% of the human population. The symptoms of infection are herpetic lesions that frequently appear throughout a host's life in response to stress in the orofacial or …
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Einfluss der MAP-Kinase ERK3 (p97) auf EBV-positive Burkitt-Lymphom-Zellen
In previous papers it was shown that Epstein-Barr Virus (EBV), a double stranded-DNA-Virus of the herpes virus family, is able to immortalize B-Cells. This assists the development of cancer as the Burkitt-Lymphoma.It was also shown, that stimulation of Epstein-Barr-Virus-genome-positive …
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The role of gylcoprotein K (gK) in the ocular and neuropathogenesis of herpes simplex virus-type 1 (HSV-1)
<p>Herpes simplex virus type 1 (HSV-1) is a DNA virus that is a ubiquitous pathogen of humans. The hallmark of the HSV-lifecycle is infection of a mucosal surface with spread to sensory neurons where the virus establishes a latent infection with periodic recurrences for the life of the host. The …
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The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection
As obligate intracellular parasites, viruses rely on host cells to replicate. Hsv-1 is a large double stranded DNA virus which is the cause of common cold sores and corneal blindness in humans. The defining feature of HSV-1 is its ability to exist in two discrete states. During lytic infection, …
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Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation
… class I: MHCI) antigen presentation can help viruses to evade cytotoxic T-lymphocyte: CTL) detection and clearance. Cowpox virus, like other orthopoxvirus family members, is a large DNA virus, whose genomic termini encode numerous immunomodulatory genes, including two ER-resident MHCI …
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