Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"DNA Shape"”.
-
Quantifying the functional and evolutionary relationships among sequences, transcription factor binding and gene expression
… studies have discussed how TFs recognize their DNA binding sites. However, it is not well understood how the various factors that influence TF-DNA binding alter the cascade of gene expression. Moreover, mutations in regulatory sequences are a key driving force of evolution and diseases. A number …
-
Structural basis for the function of the transcriptional regulator KstR from Mycobacterium tuberculosis
… Mtb. The interactions between KstR and cognate DNA or ligands have been investigated by multiple biochemical techniques (i.e. electrophoretic mobility shift assay, surface plasmon resonance and intrinsic fluorescence quenching assay). Protein-DNA binding assays have demonstrated that the …
-
Elucidating the mechanistic impact of single nucleotide variants in model organisms
… organisms for which little data is available. TF-DNA binding is another mechanism driven by sequence motifs, which is key for the tight regulation of gene expression and can be greatly altered by genetic variation. We have comprehensively benchmarked current methods used to predict non-coding …
-
Bioinspired fabrication and assembly of hybrid materials for sensing and biomedical applications
… a variety of nanomaterials with unique size- and shape- dependent physiochemical properties. However, to create hybrid bio-nanomaterials for practical applications, there are two challenges that have to be overcome. First, control over the synthesis of nanomaterials with well tailored shapes and …