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Showing 1 to 20 of 367 for “"DNA Sequences"”.
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Modeling evolution of protein coding DNA sequences
… Existing models for evolution of protein coding sequences allow site to site variation in non-synonymous substitution rates, but assume that the rate of synonymous substitutions is constant for all sites. New models provide a rigorous statistical framework for testing the hypothesis of synonymous …
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Gyper: A graph-based HLA genotyper using aligned DNA sequences
… hafa margar aðferðir sprottið upp sem nota DNA raðgreiningargögn í sama tilgangi vegna mikils aðgengis að slíkum gögnum. Helsti kostur slíkra aðferða er að þær krefjast aðeins tölvu og DNA raðgreiningargagna. Galli þeirra er að þær eru tímafrekar, oft þarf klukkustundir eða jafnvel daga til …
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Extracting regulatory signals from DNA sequences using syntactic pattern discovery
(cont.) algorithm was validated on synthetic as well as real datasets. When tested on a set of 30 well-studied regulons in Escherichia Coli, with known instances of regulatory motifs collected from biological literature, the algorithm showed, in 14 cases, a high sensitivity and specificity of 70% …
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Joint base-calling of two DNA sequences with factor graphs
The advent of DNA sequencing has revolutionized biological research by providing virtual blueprints of living organisms and offering insights into complicated biochemical processes. DNA sequencing is a process encompassing both chemical reactions and signal processing techniques to identify the …
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Optical diffraction-based silicon sensors for the detection of DNA sequences
… substrates for the detection of complementary DNA sequences using colloidal gold labels. In-depth analysis of variations of DNA sequence within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis …
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Solution structure of unusual DNA sequences by high resolution NMR spectroscopy
Unusual DNA sequences are known to adopt interesting three-dimensional structures which might have important biological roles. For my thesis, I have tried to study the influence of various degrees of perturbations of DNA backbone, sequences, pH etc. on DNA structure by a quantitative NMR procedure …
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Selection and localization of cloned DNA sequences from human chromosome 11
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 1980
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A strategy for selecting zinc finger proteins for desired DNA sequences
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Genomic organization of microdissected Y-chromosomal lampbrush loop DNA sequences of Drosophila hydei
Contains fulltext : mmubn000001_055859941.pdf (Publisher’s version ) (Open Access)
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Investigations of Phylogenetic Relationships of the Percidae (Actinopterygii: Perciformes) Using Comparative DNA Sequences
… at three hierarchical levels. First, complete sequences from two mitochondrial genes (cytochrome b and 16S rRNA) and a portion of a single-copy nuclear gene (Tmo-4C4) were used to estimate phylogenetic relationships among percid genera. Hypotheses resulting from phylogenetic analyses identify …
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DNA sequences required for efficient transcription of the estrogen regulated Xenopus laevis vitellogenin promoter
… region of target genes. In order to identify the DNA sequences essential for estrogen-regulated and liver-specific vitellogenin gene expression, we employed site-specific mutagenesis to create a variety of deletions, mutations, and insertions in the 5$\sp\prime$-flanking region of the vitellogenin …
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Repetitive DNA sequences in maize: Possible roles in plant adaptation and transient gene expression
Fluctuations as high as 40% in the nuclear DNA content in maize have been observed as a result of adaptive response. The knob DNA sequence has been reported to contribute 16% of this variation. Other DNA sequences involved in genome size variation due to adaptive response have yet to be identified. …
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Selective Enrichment Through Capture (SEC): A Technology for Retrieving Specific DNA Sequences from Complex Mixtures
The capacity to selectively target DNA sequences within a complex mixture is a useful feature for genomic studies. Several methods aimed at undertaking this feat have utilized biotinylated oligonucleotides and streptavidin beads to capture DNA but have low efficiencies, require PCR, or cannot be …
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Analysis of FokI Cleavage Resistance Observed in DNA Sequences Generated via the Combinatorial Selection Method, REPSA
… restriction endonuclease that recognizes the DNA sequence, 5’-GGATG-3’, and cleaves outside of this site 9 and 13 base-pairs downstream. The shifted cleavage function possessed by this kind of endonuclease is utilized in many applications including the combinatorial selection method, REPSA. …
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Variation and Divergence of Repetitive DNA Sequences With Partial Identity to the Knob Sequence in Tripsacum and Zea
Sequences with various levels of homology to knob have been isolated from T. dactyloides. These sequences have various degrees of cross-hybridization to knob and are apparently arranged differently in the genome as ascertained by southern blotting. Phylogenetic variation of these sequences …
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Know Thy Cell-Free DNA: Early Detection of Microsatellite Instability Using Ultra-Low-Pass Cell-Free DNA Sequences
Microsatellites are short segments of repeated DNA motifs (i.e., base pair patterns) that are widespread in our genomes. Microsatellites are inherently more mutable than other genomic locations, and since cancer cells undergo many more cell divisions, microsatellites are useful for distinguishing …
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Generic concepts in the Crepidotaceae as inferred from nuclear large subunit ribosomal DNA sequences, morphology, and basidiospore dormancy patterns
… using nuclear large subunit ribosomal DNA (LSU rDNA) sequences. Parsimony analysis of the molecular data supports the Singer classification of Crepidotus, Melanomphalia, and Simocybe as a single monophyletic unit within the Agaricales. The affinities of the genus Tubaria remain …
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Improving Reliability in DNA based Computations with Applications to Cryptography
DNA computing has become an attractive alternative to traditional computing techniques due to the large storage capacity of DNA, massive parallelism and energy efficiency of the computations. However, since DNA computing is based on bio-molecular reactions, it is not error free. One of the main …
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